A0A2I0TT16 · A0A2I0TT16_LIMLA
- Proteinreceptor protein-tyrosine kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1385 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 1098-1106 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1124 | ATP (UniProtKB | ChEBI) | |||
Active site | 1188 | Proton acceptor | |||
Binding site | 1192 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basal plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | hepatocyte growth factor receptor activity | |
Biological Process | cell migration | |
Biological Process | liver development | |
Biological Process | neuron differentiation | |
Biological Process | pancreas development | |
Biological Process | positive regulation of kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Charadriiformes > Scolopacidae > Limosa
Accessions
- Primary accessionA0A2I0TT16
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 964-987 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5014196017 | 22-1385 | receptor protein-tyrosine kinase | ||
Disulfide bond | 100↔103 | ||||
Disulfide bond | 130↔138 | ||||
Disulfide bond | 169↔172 | ||||
Disulfide bond | 293↔363 | ||||
Disulfide bond | 381↔402 | ||||
Disulfide bond | 382↔417 | ||||
Disulfide bond | 521↔539 | ||||
Disulfide bond | 527↔561 | ||||
Disulfide bond | 530↔546 | ||||
Disulfide bond | 542↔552 | ||||
Modified residue | 1218 | Phosphotyrosine; by autocatalysis | |||
Modified residue | 1219 | Phosphotyrosine; by autocatalysis | |||
Modified residue | 1333 | Phosphotyrosine; by autocatalysis | |||
Modified residue | 1340 | Phosphotyrosine; by autocatalysis | |||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 27-516 | Sema | |||
Domain | 1092-1325 | Protein kinase | |||
Region | 1345-1385 | Disordered | |||
Compositional bias | 1358-1385 | Acidic residues | |||
Sequence similarities
Belongs to the plexin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,385
- Mass (Da)151,847
- Last updated2018-02-28 v1
- Checksum032224F8E9232481
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1358-1385 | Acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KZ507378 EMBL· GenBank· DDBJ | PKU36954.1 EMBL· GenBank· DDBJ | Genomic DNA |