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A0A2I0TPK2 · A0A2I0TPK2_LIMLA

Function

function

Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.
Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentlysosome
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Processepithelial cell differentiation involved in prostate gland development
Biological Processprostate gland growth
Biological Processregulation of lipid metabolic process
Biological Processsphingolipid metabolic process

Names & Taxonomy

Protein names

  • Recommended name
    Prosaposin

Gene names

    • ORF names
      llap_13960

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Charadriiformes > Scolopacidae > Limosa

Accessions

  • Primary accession
    A0A2I0TPK2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-23
ChainPRO_501419886224-387Prosaposin

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-62Saposin A-type
Domain64-147Saposin B-type
Domain166-252Saposin B-type
Domain268-349Saposin B-type
Domain351-387Saposin A-type

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    387
  • Mass (Da)
    42,584
  • Last updated
    2018-02-28 v1
  • MD5 Checksum
    9C28180F2C8BF6A4253E1EB6B67C5F41
MESRWSGWVLILSVCLGSYQAGASPLHQCNERPEDWCRDVATAAKCGALELCRITVWDQALGQKGIPCHLCQMAVSVVGKILQDNRTEEKLRVFLDKKCQYLPFQDWSVKCKKMVDTGILILVQLGKQVLSDPKVVCGTIKLCQPRESPTGALKFQESSPASTGPAQDFADLVTPFIANVPLLLHPQDLPRGEAQEQLVNDIEKVCYMLPHGVIGQCKDFVDSYGKAVVIMLLEATDPAAVCTMLHCCPRSGDTHRGAAALEQLAVGAGAFCNVCQIVITYFDNELLKNETLAELGDVLEKGCELLPTPLTSKCEALVVQYEPAAVRLLVQMMDPNFVCTKIRACDSPEEDLLGSDPCAWGPQYWCKNMATAVECQAVEHCQRHLWN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ508071
EMBL· GenBank· DDBJ
PKU35737.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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