A0A2I0MV52 · A0A2I0MV52_COLLI

Function

function

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
    EC:3.4.21.7 (UniProtKB | ENZYME | Rhea)

Activity regulation

Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site158L-lysine (UniProtKB | ChEBI)
Binding site172L-lysine (UniProtKB | ChEBI)
Binding site429L-lysine (UniProtKB | ChEBI)
Binding site442L-lysine (UniProtKB | ChEBI)
Active site614Charge relay system
Active site657Charge relay system
Active site752Charge relay system

GO annotations

AspectTerm
Cellular Componentextracellular space
Molecular Functionserine-type endopeptidase activity
Molecular Functionsignaling receptor binding
Biological Processblood coagulation
Biological Processfibrinolysis
Biological Processproteolysis
Biological Processtissue remodeling

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Plasminogen
  • EC number

Gene names

    • ORF names
      A306_00000619

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Columbimorphae > Columbiformes > Columbidae > Columba

Accessions

  • Primary accession
    A0A2I0MV52

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_501415978020-802Plasminogen
Disulfide bond185↔262
Disulfide bond206↔245
Disulfide bond234↔257
Disulfide bond275↔352
Disulfide bond296↔335
Disulfide bond324↔347
Disulfide bond374↔451
Disulfide bond395↔434
Disulfide bond423↔446

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-98Apple
Domain102-181Kringle
Domain184-262Kringle
Domain274-352Kringle
Domain373-451Kringle
Domain472-552Kringle
Domain573-800Peptidase S1

Sequence similarities

Belongs to the peptidase S1 family. Plasminogen subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    802
  • Mass (Da)
    90,789
  • Last updated
    2018-02-28 v1
  • Checksum
    092D8151037EEC53
MEISKAAFLFLFLLSSVEGNILDNYVRTEGAWLLNPKKQLYKTNSKEECAERCETEIKFNCRAFLFTSKDQQCLTLAENTKTAVIFRRTNAVLYEKRIYLLECKKGKGVDYRGSEAKTQKGVPCQNWADNSPHKPNYTPEKYPDAGLEENYCRNPDNDEKGPWCYTTDPATRFDYCNIPECEVECMHCSGENYHGVVATTESGLECQRWDSQQPHSHGYLPENFPEKDLKMNYCRNPDGEPRPWCFTTSPTKRWEYCDIPRCTTPPPVPAPGRQCLSGRGEDYRGTISITESGNTCQRWSSQSPHRHARTPENYPCKSLEENYCRNPDGEKMPWCYTTNRTARWEYCTIPSCDGTEPEAPAVDVPEQAQITEECYQGNGVTYRGTASFTLTGKKCQAWSSMSPHRHNKTAEQFPNADLRQNYCRNPDADTRPWCYTTDPSVRWEYCNLKRCDIHVPVTLPKPPQTTLEPNPDCINGNGKDYRGTVAKTARGRTCQEWSSQKPHSHDYFTPMTHPGAGLDKNYCRNPDGDVNGPWCYTTDPRKAWEYCDIPKCPPAQYECGKAKFRPKLCAQRIVAGCISNPHSWPWQISLRTSFGLHFCGGTLIDPQWVLTAAHCLEKSSRPSAYKVYLGLHRERASEASVQKRDVEKLFKEPHRADIALLKLSSPAVITDHVIPVCLPKENTVLGGREECYVTGWGETKGTGGDGYLKETGFPVIENKICNRPEFLNGRVKKHELCAGNIHGGTDSCQGDSGGPLVCLNQDKFVQHGVTSWGLGCAQPMKPGVYVRVSNYIPWIKSVMESY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AKCR02000002
EMBL· GenBank· DDBJ
PKK33559.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp