A0A2I0KC25 · A0A2I0KC25_PUNGR

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by AMP.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site101ATP (UniProtKB | ChEBI)
Binding site164-165ATP (UniProtKB | ChEBI)
Binding site189-192ATP (UniProtKB | ChEBI)
Binding site190Mg2+ (UniProtKB | ChEBI); catalytic
Site191Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site218-220substrate
Active site220Proton acceptor
Binding site263-265substrate
Binding site319substrate
Binding site375-378substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      PFK
    • ORF names
      CRG98_013497

Organism names

  • Taxonomic identifier
  • Strain
    • cv. AG2017
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Myrtales > Lythraceae > Punica

Accessions

  • Primary accession
    A0A2I0KC25

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain95-399Phosphofructokinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    487
  • Mass (Da)
    53,550
  • Last updated
    2018-02-28 v1
  • Checksum
    832A85D8C47F5BA7
MGISGVSKAKIVRGDCGYVLEDVPHFSDYIRDLPNYPNPLQDNPAYSVVKQYFVDLDDTVAQKVIAHKNGPRGLHFRRAGPRQKVYFESDDVHACIVTCGGLCPGLNTVIREIVCGLYHMYGVKKVLGIEGGYKGFYSRNTVLLNPKVVNDIHKRGGTILGTSRGGHDTTKIVDSIQDRGINQVYIIGGDGTQKGAAVIFEEIKRRGLKVAVAGIPKTIDNDIPVTDRSFGFDTAVEEAQRAINAAHVEAESVENGIGVVKLMGRYSGFIAMHATLASRDVDCCLIPESPFYLEGAGGLFEFIEKRLKENGHMVIVIAEGAGQDLFSESIHSVDKDASGNRLLQDVGLWLSQKIKEHFAKKNKMDITLKYIDPTYMIRAVPSNASDNVYCTLLAQSAVHGAMAGYTGFTVGLVNGRHSYIPFYRITEKQNKVVITDRMWARLLSSTNQPSFLSPKDIIEDKKEGSSPALVDDHDTVDGYLVNKEINY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PGOL01000690
EMBL· GenBank· DDBJ
PKI66089.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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