A0A2I0BXS3 · A0A2I0BXS3_PLAFO

Function

function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site15ATP (UniProtKB | ChEBI)
Binding site17ATP (UniProtKB | ChEBI)
Binding site18ATP (UniProtKB | ChEBI)
Binding site19ATP (UniProtKB | ChEBI)
Binding site20ATP (UniProtKB | ChEBI)
Binding site127ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processphosphorylation
Biological Processribosomal small subunit biogenesis
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase isoenzyme 6 homolog
  • EC number
  • Short names
    AK6
  • Alternative names
    • Dual activity adenylate kinase/ATPase
      (AK/ATPase
      )

Gene names

    • ORF names
      CK202_2192
      , CYL21_3548

Organism names

  • Taxonomic identifier
  • Strain
    • NF54
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)

Accessions

  • Primary accession
    A0A2I0BXS3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region48-71NMPbind
Region126-136LID

Sequence similarities

Belongs to the adenylate kinase family. AK6 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    186
  • Mass (Da)
    22,173
  • Last updated
    2018-02-28 v1
  • Checksum
    FB1B6DA31269F972
MKRKVPNIIITGVPGSGKSTLCEELKEIINKELLKRNDMEGFEMTHLNLSNIIKDERLYKEFDDELDASIYSEELLNEYLKKKYKLEKGGYIIDFHDINFVKDVDIIDKIFLLTIQTNFLYERLEKRNYTKEKIKNNIECEIFQVIKEDILDHFPNTNILQEIENNDLQQYDNNLSIIKNWVLSYI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QFXU01000016
EMBL· GenBank· DDBJ
KAF4328329.1
EMBL· GenBank· DDBJ
Genomic DNA
NYMT01000005
EMBL· GenBank· DDBJ
PKC48084.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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