A0A2I0APY7 · A0A2I0APY7_9ASPA
- ProteinPhosphatidyl-N-methylethanolamine N-methyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids461 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
Catalytic activity
- 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H+ + S-adenosyl-L-homocysteine
Pathway
Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | phosphatidyl-N-dimethylethanolamine N-methyltransferase activity | |
Molecular Function | phosphatidyl-N-methylethanolamine N-methyltransferase activity | |
Molecular Function | phosphatidylethanolamine N-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | phosphatidylcholine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidyl-N-methylethanolamine N-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Asparagales > Orchidaceae > Apostasioideae > Apostasia
Accessions
- Primary accessionA0A2I0APY7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-298 | Lumenal | ||||
Sequence: MPSFLTATSTPQSARRSPFLERESFGRTEKVYAIERTEREREEREGGERRVRKWVRRAHSIFKVGWVRTAPHHGKRRQEFSLRSSLLCAQILFLRIKKRPTRSTGLQRTNPTGGTAMEQMRSAYAPISPEAKRKNLLIDGREKADTPESLQSTQHRNEAVTVRNRGSGPLLFEQVRAAKSANGNSGKHKINREIEEDGRRPPTSSEHSNNIISLGGETIKELERSRRIAACGRERQKPAKQGEQEQRQRAFVAFAGQRKELIDKFWGDGWDRTEPATESAPRLGNHRLFGQGSMAAAA | ||||||
Transmembrane | 295-318 | Helical | ||||
Sequence: AAAAATAAVVLGTMAPFPFYYFLW | ||||||
Intramembrane | 299-319 | Helical | ||||
Sequence: ATAAVVLGTMAPFPFYYFLWS | ||||||
Transmembrane | 415-440 | Helical | ||||
Sequence: YVGSILSLVACSCWVPLKYLLLWILG | ||||||
Topological domain | 450-461 | Cytoplasmic | ||||
Sequence: MEDPATRAKPFS |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 144-210 | Disordered | ||||
Sequence: ADTPESLQSTQHRNEAVTVRNRGSGPLLFEQVRAAKSANGNSGKHKINREIEEDGRRPPTSSEHSNN | ||||||
Compositional bias | 186-203 | Basic and acidic residues | ||||
Sequence: GKHKINREIEEDGRRPPT |
Sequence similarities
Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length461
- Mass (Da)52,555
- Last updated2018-02-28 v1
- Checksum5E871EA7038C702D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 186-203 | Basic and acidic residues | ||||
Sequence: GKHKINREIEEDGRRPPT |
Keywords
- Technical term