A0A2H9SHY2 · A0A2H9SHY2_9GAMM

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      CK424_02735

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BC.3.72
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Legionellales > Legionellaceae > Legionella

Accessions

  • Primary accession
    A0A2H9SHY2

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane17-36Helical
Transmembrane48-69Helical
Transmembrane81-100Helical
Transmembrane106-128Helical
Transmembrane140-158Helical
Transmembrane170-192Helical
Transmembrane227-250Helical
Transmembrane262-284Helical
Transmembrane296-317Helical
Transmembrane323-342Helical
Transmembrane354-377Helical
Transmembrane397-418Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-419Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    428
  • Mass (Da)
    47,204
  • Last updated
    2018-02-28 v1
  • Checksum
    B0E2D796247D73DB
MSRSHHSGKTKRDFKPWLIWGLGCLFYFYECLLQVSPSVMSSELMRDFSVTSHTLGILSGIYFYSYAGMQLPCGLMTDYFGPRRLLTIATTICAISTIAFGLTENFFMACIARLMIGFGSAFAVVGTLKLASNWFPANRFAFLTGMMVTLGMLGAIFGEAPLAVLIDHYGWRHSMLIMGCIGLIVALLIFTFTKDHGTHVYQTASEDTKEEGSIGQRLLILLRNKQLWLVAFYGGLIYTATPVICGLWGVPFLMLSMHLPKAVAANYISLILFGWALAGPLWGIFSNKIGLRKPPLYIGGIGALITSSLFILCPIQNKIVMQILLFAFGIFSAGFLPAFALAKELCNQKYVATALSFMNMMNMVGIAIVQPAVGFILDSLWSGQMEHNVRIYTVENYHTALAVLPIGMLIAVMLLPFIHETHCKAAVK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PEQK01000009
EMBL· GenBank· DDBJ
PJD93322.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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