A0A2H6J849 · A0A2H6J849_UNCXX
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- Genedut
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids152 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = dUMP + diphosphate + H+
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 71-73 | substrate | ||||
Sequence: RSG | ||||||
Binding site | 84 | substrate | ||||
Sequence: N | ||||||
Binding site | 88-90 | substrate | ||||
Sequence: LID |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageBacteria
Accessions
- Primary accessionA0A2H6J849
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-150 | dUTPase-like | ||||
Sequence: IPPPDYATAGAAGLDLRACLDAPITLAAGETTLIPTGIAIHIDDPGLAAVLLPRSGLGHKHGIVLGNLVGLIDSDYQGQVFVSCWNRGGAPFTIEIGERIAQMVFMPVVQARFERVEEFEASARGAGGFGHSG |
Sequence similarities
Belongs to the dUTPase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length152
- Mass (Da)16,066
- Last updated2018-02-28 v1
- ChecksumF1106FC66EB3A9CF