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A0A2H6BDA0 · A0A2H6BDA0_9HYPH

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site33-40ATP (UniProtKB | ChEBI)
Active site40Proton donor
Binding site64(R)-pantoate (UniProtKB | ChEBI)
Binding site64beta-alanine (UniProtKB | ChEBI)
Binding site150-153ATP (UniProtKB | ChEBI)
Binding site156(R)-pantoate (UniProtKB | ChEBI)
Binding site187-190ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • ORF names
      METY_1374

Organism names

  • Taxonomic identifier
  • Strain
    • Yamaguchi
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylopilaceae > Methylopila

Accessions

  • Primary accession
    A0A2H6BDA0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    284
  • Mass (Da)
    30,072
  • Last updated
    2018-02-28 v1
  • MD5 Checksum
    528E3A86329C627E15F1A4E5F3D424CF
MSRPAVVTTVAELRAHLKPWRQAGERIALVPTMGALHAGHISLVRIGQARAERVVTSIFVNPKQFAPTEDLATYPRDFDGDLEKLAEAGVDLVFAPEAAEMYPEGEATVVTVGGPSAGLESDARPHFFAGVATVVTKLLIQCAPDVAIFGEKDFQQLAVIRTLTRDLALPTEIVAGATMREPDGLAMSSRNLYLNKDDRRRATALSAALAAAGEAIEDGAPADAALLSARRAIEAAGFTIDYVELRDAETLSASTRPGKPRRLLAAARIGGVRLIDNIAVAAAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BAUX01000004
EMBL· GenBank· DDBJ
GBD48161.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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