A0A2H5YW48 · A0A2H5YW48_UNCXX

  • Protein
    Endonuclease V
  • Gene
    nfi
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.
    EC:3.1.21.7 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, site.

124320406080100120140160180200220240
TypeIDPosition(s)Description
Binding site52Mg2+ (UniProtKB | ChEBI)
Site100Interaction with target DNA
Binding site130Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondeoxyribonuclease V activity
Molecular Functionmagnesium ion binding
Molecular FunctionRNA endonuclease activity, producing 5'-phosphomonoesters
Molecular Functionsingle-stranded RNA binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease V
  • EC number
  • Alternative names
    • Deoxyinosine 3'endonuclease
    • Deoxyribonuclease V
      (DNase V
      )

Gene names

    • Name
      nfi
    • ORF names
      HRbin27_00151

Organism names

Accessions

  • Primary accession
    A0A2H5YW48

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the endonuclease V family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    243
  • Mass (Da)
    27,084
  • Last updated
    2018-02-28 v1
  • Checksum
    D0F39C8A70A81CFC
MGDRRHRWHRGTVPEGISAEELERLADLQRELAAKVIECPLTRPPRFVAGADVHLRNDIAIAVAVLQETLDQPMDDQDVRPLPLREVERVTVRTQIAFPYIPGFLSFREAPALLEAIRGLSRPPDLLVLDGQGRAHPRGCGLASHVGVLLDLPTIGAAKSRLYGRYQEPPNERGAWSPLIADGTVIGATLRTRPNTKPLIVSVGHRITLAEAILWTLRLSRYRLPEPTRWAHRYAKEAVAALR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BEID01000012
EMBL· GenBank· DDBJ
GBD17667.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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