A0A2H4ZEZ3 · A0A2H4ZEZ3_URSMA

Function

function

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin cytoskeleton
Cellular Componentaxon terminus
Cellular Componentcell cortex
Cellular Componentcytosol
Cellular Componentextracellular space
Cellular Componentgrowth cone
Cellular Componentinclusion body
Cellular Componentmitochondrion
Cellular Componentneuronal cell body
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componentplatelet alpha granule membrane
Cellular Componentpostsynapse
Cellular Componentprotein-containing complex
Cellular Componentsupramolecular fiber
Cellular Componentsynaptic vesicle membrane
Molecular Functionactin binding
Molecular Functionalpha-tubulin binding
Molecular Functionarachidonic acid binding
Molecular Functioncalcium ion binding
Molecular Functioncuprous ion binding
Molecular Functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
Molecular Functiondynein complex binding
Molecular Functionferrous iron binding
Molecular Functionhistone binding
Molecular FunctionHsp70 protein binding
Molecular Functionidentical protein binding
Molecular Functionkinesin binding
Molecular Functionmagnesium ion binding
Molecular Functionoxidoreductase activity
Molecular Functionphospholipid binding
Molecular Functionphosphoprotein binding
Molecular FunctionSNARE binding
Molecular Functiontau protein binding
Molecular Functionzinc ion binding
Biological Processactivation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Processadult locomotory behavior
Biological Processcellular response to copper ion
Biological Processcellular response to oxidative stress
Biological Processdopamine biosynthetic process
Biological Processexcitatory postsynaptic potential
Biological Processfatty acid metabolic process
Biological Processlong-term synaptic potentiation
Biological Processmicroglial cell activation
Biological Processmitochondrial ATP synthesis coupled electron transport
Biological Processmitochondrial membrane organization
Biological Processnegative regulation of chaperone-mediated autophagy
Biological Processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Processnegative regulation of dopamine uptake involved in synaptic transmission
Biological Processnegative regulation of exocytosis
Biological Processnegative regulation of microtubule polymerization
Biological Processnegative regulation of monooxygenase activity
Biological Processnegative regulation of neuron apoptotic process
Biological Processnegative regulation of norepinephrine uptake
Biological Processnegative regulation of platelet-derived growth factor receptor signaling pathway
Biological Processnegative regulation of serotonin uptake
Biological Processnegative regulation of thrombin-activated receptor signaling pathway
Biological Processnegative regulation of transporter activity
Biological Processneuron apoptotic process
Biological Processneutral lipid metabolic process
Biological Processphospholipid metabolic process
Biological Processpositive regulation of endocytosis
Biological Processpositive regulation of exocytosis
Biological Processpositive regulation of glutathione peroxidase activity
Biological Processpositive regulation of hydrogen peroxide catabolic process
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of inositol phosphate biosynthetic process
Biological Processpositive regulation of neurotransmitter secretion
Biological Processpositive regulation of peptidyl-serine phosphorylation
Biological Processpositive regulation of protein localization to cell periphery
Biological Processpositive regulation of protein serine/threonine kinase activity
Biological Processpositive regulation of receptor recycling
Biological Processpositive regulation of release of sequestered calcium ion into cytosol
Biological Processpositive regulation of SNARE complex assembly
Biological Processprotein destabilization
Biological Processprotein tetramerization
Biological Processreceptor internalization
Biological Processregulation of acyl-CoA biosynthetic process
Biological Processregulation of dopamine secretion
Biological Processregulation of glutamate secretion
Biological Processregulation of locomotion
Biological Processregulation of long-term neuronal synaptic plasticity
Biological Processregulation of macrophage activation
Biological Processregulation of phospholipase activity
Biological Processregulation of presynapse assembly
Biological Processregulation of transmembrane transporter activity
Biological Processresponse to interleukin-1
Biological Processresponse to iron(II) ion
Biological Processresponse to lipopolysaccharide
Biological Processresponse to magnesium ion
Biological Processresponse to type II interferon
Biological Processresponse to xenobiotic stimulus
Biological ProcessSNARE complex assembly
Biological Processsynapse organization
Biological Processsynaptic transmission, dopaminergic
Biological Processsynaptic vesicle endocytosis
Biological Processsynaptic vesicle priming
Biological Processsynaptic vesicle transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-synuclein

Gene names

    • Name
      SNCA

Organism names

Accessions

  • Primary accession
    A0A2H4ZEZ3

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis. Interacts with UCHL1. Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity. Interacts with RPH3A and RAB3A. Interacts with SERF1A; this interaction promotes the aggregation of SNCA. Interacts with SEPTIN4.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region95-140Disordered
Compositional bias116-140Acidic residues

Sequence similarities

Belongs to the synuclein family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    140
  • Mass (Da)
    14,479
  • Last updated
    2018-02-28 v1
  • MD5 Checksum
    6F1114CFA829752B771AF57E038F9983
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDQLGKSEEGGPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias116-140Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY471141
EMBL· GenBank· DDBJ
AUF74483.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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