A0A2H4V2R2 · A0A2H4V2R2_9MAGN

  • Protein
    ATP-dependent Clp protease proteolytic subunit
  • Gene
    clpP
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.

Catalytic activity

  • Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
    EC:3.4.21.92 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

120120406080100120140160180200
TypeIDPosition(s)Description
Active site100
Active site100Nucleophile
Active site125

GO annotations

AspectTerm
Cellular Componentchloroplast stroma
Cellular Componentendopeptidase Clp complex
Molecular FunctionATP-dependent peptidase activity
Molecular FunctionATPase binding
Molecular Functionserine-type endopeptidase activity
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent Clp protease proteolytic subunit
  • EC number
  • Alternative names
    • Endopeptidase Clp

Gene names

    • Name
      clpP

Encoded on

  • Chloroplast

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Ranunculales > Ranunculaceae > Ranunculoideae > Delphinieae > Aconitum

Accessions

  • Primary accession
    A0A2H4V2R2

Subcellular Location

Keywords

Interaction

Subunit

Component of the chloroplastic Clp protease core complex.

Family & Domains

Sequence similarities

Belongs to the peptidase S14 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    201
  • Mass (Da)
    22,429
  • Last updated
    2018-02-28 v1
  • Checksum
    EE020C13B1BA92CA
MPIGVPKVPFRSPGEEDAIWVDIYRLHRERLLFLGQGVNSAISNQLIGLMVYLSIEDETRDLYLFINSPGGWLIPGVAIYDTMQFVLPDVHTICMGLAASMASFLLVGGEITKRIAFPHARVMIHQPASSFYKAQTGEFILEAEELLKLRETLTRVYVQRTGKPLWVVSEDMERDVFMSATEAQAHGIVDLVAAENAGDFT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF186593
EMBL· GenBank· DDBJ
AUB29897.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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