A0A2H4U2B6 · A0A2H4U2B6_EMEND

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Mo-molybdopterin (UniProtKB | Rhea| CHEBI:71302 )

Note: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 2 [2Fe-2S] clusters.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site49[2Fe-2S] cluster 1 (UniProtKB | ChEBI)
Binding site54[2Fe-2S] cluster 1 (UniProtKB | ChEBI)
Binding site57[2Fe-2S] cluster 1 (UniProtKB | ChEBI)
Binding site78[2Fe-2S] cluster 1 (UniProtKB | ChEBI)
Binding site117[2Fe-2S] cluster 2 (UniProtKB | ChEBI)
Binding site120[2Fe-2S] cluster 2 (UniProtKB | ChEBI)
Binding site161[2Fe-2S] cluster 2 (UniProtKB | ChEBI)
Binding site163[2Fe-2S] cluster 2 (UniProtKB | ChEBI)
Binding site312-319FAD (UniProtKB | ChEBI)
Binding site397FAD (UniProtKB | ChEBI)
Binding site420FAD (UniProtKB | ChEBI)
Binding site483FAD (UniProtKB | ChEBI)
Binding site821Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Binding site852Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Binding site856substrate
Binding site934substrate
Binding site966Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Binding site968substrate
Binding site1135Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Active site1327Proton acceptor

GO annotations

AspectTerm
Molecular Function2 iron, 2 sulfur cluster binding
Molecular FunctionFAD binding
Molecular Functioniron ion binding
Molecular Functionoxidoreductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    xanthine dehydrogenase
  • EC number

Gene names

    • Name
      hxnS

Organism names

  • Taxonomic identifier
  • Strain
    • HZS.145
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes

Accessions

  • Primary accession
    A0A2H4U2B6

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain10-962Fe-2S ferredoxin-type
Region192-221Disordered
Compositional bias205-219Polar residues
Domain284-473FAD-binding PCMH-type

Sequence similarities

Belongs to the xanthine dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,396
  • Mass (Da)
    153,171
  • Last updated
    2018-02-28 v1
  • Checksum
    40E9F26977450407
MDALLPRSSPQLKFYLNGTPISLTSPHPRWTLLDFIRSQDGLKGTKLGCGEGGCGACTVVLQTRQHGKKIRHLAVNACLYPLIGVSGKHVITIEGLGTVDHPHPLQERIAQLHGSQCGFCTPGIVMSLYAMIRNAYDPVTGKFQLSADDIESKGHLDGNLCRCTGYKPILNAARTFIEDDLGSVPSIVESELVGTEEETESDMGAHSGSGDTGSRSSGSCGRPGGCCKDSPGISSCSSRETDMTTPSLPDSPVLKQYDFIPYTPTTELIYPPGLAKFVPELLCYGDAEQAWVKPRSVQEALEILSQCPSATLVTGASEVQVDVRFKDFRPSVSVFVGDITEMTGISWSEDMKTLYIGGSASLSDIEAECLRCIPLLKAVNLGSESVLSAIARTLRYFAGRQIRNAACLAGNIATASPISDMNPLLLAVGATVHARTSAEETTIPMSEMFKGYRKTALPSGSLITKIAVPMPSKDQIEIVNAYKQAKRKDDDIAIVTAAFRVRIAPGPDYTVQEASLAFGGMAPTTVLAHKTASALEGKRWGDEAVLDIVLTSLGEEFNLPYSVPGGMATYRRTLTLSLFVRFWNYVNQKLGLEYDSDLIEEIHRGISTGTRDDDNPHAQRVVGQQIPHLSGLKHATGEAEYVDDMPPLHRELHGALVLSERAHAKILSVNWTPALERGAVGYVDHTSLPEEKNHWGPVVHDEPVFAKGEVHAHGQPIGLVYADDAMTAQIAAKAVIVTYEDLPAILTIDEAIEARSFFNYGKELRRGAPPEEIRKELDDCEYTLSGTTKIGGQEHFYLETNAAIAVPHTEDGSMDVWSSTQNTMETQDFLSQVTNVPRHKINARVRRMGGAFGGKESRSVPIACIVAVAAKKARRPVRIMLNRDEDMMTSGQRHPVQCRWKVGFNREGKLLVLDADTYNNAGYSVDMSAAVMDRCLTHIENCYYIPNVWLRGWVCKTNTHSNTAFRGFGAPQAMYITESIISAVAEKVGIDVDEIRRRNLYQVGQRTPFNQVLDEDWHVPLLLEQVREEADYDARKKEIERFNSEHRWRKRGIALIPTKFGISFATALHLNQASAAVRVYTDGSVLLNHGGTEMGQGLYTKMVQVAAQELRVPVDQVYTQDTSSYQTANASPTAASSGSDLNGMAIKHACDQINERLRPYREKYGEDADLGTIAKAAYRDRVNLSAAGYYKMPTIGYEWGNYSENVKPMYFYFTQGVACTEVELDLLTGTHTVLRADLKMDIGRSINPAIDYGQIEGAFVQGQGLFTMEESLWTRSGQLATRGPGTYKIPGFADIPQVFNVSFLQDNKEKTMWKTLRSIQSSKGIGEPPLFMGSSVLFALRDALSHARRERGVSEPLVLDSPATVERLRLAVGDDLVHRAQVQRKDGEQGFFVAVA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias205-219Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX585438
EMBL· GenBank· DDBJ
AQR59328.1
EMBL· GenBank· DDBJ
mRNA
KY962010
EMBL· GenBank· DDBJ
ATZ35992.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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