A0A2H4NPU5 · A0A2H4NPU5_9HEPC
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1523 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Cysteine protease required for the proteolytic auto-cleavage between the non-structural proteins NS2 and NS3. The N-terminus of NS3 is required for the function of NS2 protease (active region NS2-3). Promotes the initiation of viral particle assembly by mediating the interaction between structural and non-structural proteins.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Cofactor
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus
Accessions
- Primary accessionA0A2H4NPU5
Subcellular Location
UniProt Annotation
GO Annotation
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Single-pass type I membrane protein
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 217-240 | Helical | |||
Transmembrane | 297-315 | Helical | |||
Transmembrane | 677-698 | Helical | |||
Transmembrane | 710-737 | Helical | |||
Transmembrane | 744-763 | Helical | |||
Transmembrane | 775-794 | Helical | |||
Transmembrane | 850-872 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homohexamer. Homoheptamer. Interacts with protease NS2.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-22 | Basic and acidic residues | |||
Region | 1-30 | Disordered | |||
Domain | 862-985 | Peptidase C18 | |||
Domain | 986-1167 | Peptidase S29 | |||
Domain | 1176-1328 | Helicase ATP-binding | |||
Domain | 1320-1497 | Helicase C-terminal | |||
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,523
- Mass (Da)164,804
- Last updated2018-02-28 v1
- MD5 ChecksumFDA02C30D3444DE580CF51E9C090E277
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Compositional bias | 1-22 | Basic and acidic residues | |||
Non-terminal residue | 1523 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY704895 EMBL· GenBank· DDBJ | ATV93999.1 EMBL· GenBank· DDBJ | Genomic RNA |