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A0A2H4NPU5 · A0A2H4NPU5_9HEPC

Function

function

Cysteine protease required for the proteolytic auto-cleavage between the non-structural proteins NS2 and NS3. The N-terminus of NS3 is required for the function of NS2 protease (active region NS2-3). Promotes the initiation of viral particle assembly by mediating the interaction between structural and non-structural proteins.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell lipid droplet
Cellular Componenthost cell mitochondrion
Cellular Componenthost cell plasma membrane
Cellular Componentlipid droplet
Cellular Componentplasma membrane
Cellular Componentribonucleoprotein complex
Cellular Componentviral envelope
Cellular Componentviral nucleocapsid
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA helicase activity
Molecular Functionserine-type peptidase activity
Molecular Functionstructural molecule activity
Biological Processapoptotic process
Biological Processfusion of virus membrane with host endosome membrane
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processtransformation of host cell by virus
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • XJN0211
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus

Accessions

  • Primary accession
    A0A2H4NPU5

Subcellular Location

Host cell membrane
Host cytoplasm
Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Single-pass type I membrane protein
Host lipid droplet
Host mitochondrion
Host nucleus
Virion membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane217-240Helical
Transmembrane297-315Helical
Transmembrane677-698Helical
Transmembrane710-737Helical
Transmembrane744-763Helical
Transmembrane775-794Helical
Transmembrane850-872Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homohexamer. Homoheptamer. Interacts with protease NS2.

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-22Basic and acidic residues
Region1-30Disordered
Domain862-985Peptidase C18
Domain986-1167Peptidase S29
Domain1176-1328Helicase ATP-binding
Domain1320-1497Helicase C-terminal

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,523
  • Mass (Da)
    164,804
  • Last updated
    2018-02-28 v1
  • MD5 Checksum
    FDA02C30D3444DE580CF51E9C090E277
ATRKTSERSQPRGRRQPIPKARRSEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRPSWGPNDPRRRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRALEDGINFATGNLPGCSFSIFLLALFSCLIHPAASLEWRNTSGLYVLTNDCSNSSIVYEADDVILHAPGCVPCVQDGNTSTCWTPVTPTVAVKYLGATTASIRSHVDLLVGAATMCSALYVGDICGAVFLVGQAFTFRPRRHQTVQTCNCSLYPGHLTGHRMAWDMMMNWSPAVGMVVAHVLRLPQTLFDIIAGAHWGILAGLAYYSMQGNWAKVAIIMVMFSGVDAETYVSAGNMARAAGGIANLFSPGAQQKLQLVNTNGSWHINSTALNCNESINTGFIAGLFYYHRFNSTGCPQRLSSCKPITFFKQGWGPLTDANISGPSDVRPYCWHYPPRPCGVVSATTVCGPVYCFTPSPVVVGTTDARGAPTYNWGANESDVFLLESLRPPSGRWFGCAWMNSTGFLKTCGAPPCNIYGGGGDTKNESDLFCPTDCFRKHPEATYSRCGSGPWLTPRCMVDYPYRLWHYPCTVNFTLFKVRMFVGGFEHRFTAACNWTRGERCDIEDRDRSEQHPLLHSTTELAILPCSFTPMPALSTGLIHLHQNIVDVQYLYGVGSGMVGWALKWEFVILVFLLLADARVCVALWLMLMISQAEAALENLVTLNAVAVAGTHGIGWYLVAFCAAWYVRGKLVPLVTYSLTGLWSLALLVLLLPQRAYAWSGEDSATLGAGVLALFGFFTLSPWYKHWIGRLIWWNQYTICRCESALHVWIPPLLARGSRDGVILLTSLLYPSLIFDITKLLIAVLGPLYLIQASITATPYFVRAHVLVRLCMLVRSVTGGKYFQMIILSIGKWFNTYLYDHLAPMQHWAAAGLKDLAVATEPVIFSPMEIKIITWGADTAACGDILCGLPVSARLGREVLLGPADDYREMGWRLLAPITAYTQQTRGLFGTIVTSLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPPGAKSLEPCACGSADLYLVTRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGIDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEVPFYGKAIPLALLKGGRHLIFCHSKKKCDEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTG

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias1-22Basic and acidic residues
Non-terminal residue1523

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY704895
EMBL· GenBank· DDBJ
ATV93999.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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