A0A2H1JM62 · A0A2H1JM62_BRELN

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

1753100200300400500600700
TypeIDPosition(s)Description
Binding site84ATP (UniProtKB | ChEBI)
Binding site102-106ATP (UniProtKB | ChEBI)
Binding site488ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      BLIN9172_02284

Organism names

Accessions

  • Primary accession
    A0A2H1JM62

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-573SecA family profile
Domain86-246Helicase ATP-binding
Domain414-572Helicase C-terminal

Sequence similarities

Belongs to the SecA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    753
  • Mass (Da)
    83,067
  • Last updated
    2018-01-31 v1
  • Checksum
    4CF01DF6DA6BDA88
MGFFSRLLNRPGSHAEKTTGWFERAADDLDAAGREFSELSDSELTEAAGEVFASGSQQQTLIRYCALAREAGKRVLDERAYDTQLRGLVGLLQGSIVQMATGEGKTLVGALAAAGYALQGRRVHVVSVNDYLAVRDRNWMKPLFDLLGVKSASISGAQADDERRGAYRAEVVYASVTEVGFDVLRDRFLTEDADQRVPERDVVIVDEADSVLIDEARVPLVLAGSASVQDTDTAIAALVSRLSPDTDFEVSADRHAVSLTDAGVDRVEDELDVELFKEDSETLAAVNLALHARALVKRDVDYLVVDGRVKLISSSRGRVAELQRWPDGLQAAVEAKESLDATDSGEILDQMTVEELIHGYETVCGMTGTALAVGDDLREFYGLEIVPIDTHLPVIRSDEPDRLFTYQESKERAIVEEVVDNHARRRPVLIGTSSVAESESLAERLTERGIDVAVLNAKDDSREAEIIAKAGAPGAVTVSTQMAGRGTDIRLADDDVAEAGGLLVIGAGRYPSSRLDDQLRGRAGRQGDPGTSVFFTSLEDELVTRVPEIQRFVSEGDETGLIESKRALGLVEHAQRIAEGQNTALHRDTWRFNELMAKQRELVLERRAEIRKADEPVEQLRKELGDRADEIAQEHSEELLDSVLREVMLFHLDARWVDHLAFLNDLREGIHLRTFAREKPHEAFNTESIRVFSSFWSDVIDDSTATIKEATITEEGIDLESHGLKRPSSTWTYLTTENAFGSDIENIVKKVRR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FXYY01000014
EMBL· GenBank· DDBJ
SMX88434.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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