A0A2H1HR15 · A0A2H1HR15_9MICO

  • Protein
    Phosphoenolpyruvate carboxykinase [GTP]
  • Gene
    pckG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site83substrate
Binding site223-225substrate
Binding site232Mn2+ (UniProtKB | ChEBI)
Binding site252Mn2+ (UniProtKB | ChEBI)
Binding site274substrate
Binding site275-280GTP (UniProtKB | ChEBI)
Active site276
Binding site299Mn2+ (UniProtKB | ChEBI)
Binding site390-392substrate
Binding site392GTP (UniProtKB | ChEBI)
Binding site423GTP (UniProtKB | ChEBI)
Binding site517-520GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      BSP109_00195

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Mu109
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Brevibacteriaceae > Brevibacterium

Accessions

  • Primary accession
    A0A2H1HR15

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-243Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain248-606Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    610
  • Mass (Da)
    66,739
  • Last updated
    2018-01-31 v1
  • Checksum
    FBEEBDC55B863C41
MTVIDRGSVQDLLTNAPTKNPKVLDFVRSIAERTTPDAIEWITGSEEQRHSLLSRAIDTGTIVKLSGPKDSYYAASDPDDVARVEDRTFICSEKEEDAGPLNNWVAPAEMKGILNDVFAGSMRGRTMYVIPFVMGHVDATQPMFGIEVTDSPYVVLSMGIMARSGDVALEAIDRLDADFVECVHSVGAPLEPGQDDVAWPCNSTKYITQFPEERSVWSYGSGYGGNALLGKKAYALRIASAIAHDEGWLAEHMLILKLTNPEGEVKYVAAAFPSACGKTNLAMIEPNIPGWKAETLGDDIAWMRFGPDGQLYAVNPEFGLFGVAPGTGYVTNPTAMSAIEAGGNIFTNVALTDDGGVWWEGMTDEKPAHLTDWRGNDWTPDSETPAAHPNSRFCTPIANVATIAPEWQNPDGVPISAILFGGRRKTTMPLVTQTSDWNHGVFMGSILSSETTAAAVGKVGVVRRDPMAMRPFIGYNVGDYLQHWIDIGKTEGAQLPKIFYVNWFRRAEDNSFLWPGFTDNSRILKWVFERVSGTADAVQTPVGFAPVAGGIDLDGLDISEEQVQKALEVKPDEWAEELQSIDAWYDELGEHVPAELRAEVEELRDRLGVK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FXZF01000001
EMBL· GenBank· DDBJ
SMX65365.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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