A0A2G9EFE2 · A0A2G9EFE2_9FUSO
- ProteinExodeoxyribonuclease III
- Genexth
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids253 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 7 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 35 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 105 | |||||
Sequence: Y | ||||||
Active site | 144 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Binding site | 144 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 146 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Site | 146 | Transition state stabilizer | ||||
Sequence: N | ||||||
Site | 216 | Important for catalytic activity | ||||
Sequence: D | ||||||
Binding site | 241 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 242 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 242 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 242 | Interaction with DNA substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | double-stranded DNA 3'-5' DNA exonuclease activity | |
Molecular Function | endonuclease activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA repair |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Fusobacteriota > Fusobacteriia > Fusobacteriales > Fusobacteriaceae > Fusobacterium
Accessions
- Primary accessionA0A2G9EFE2
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-242 | Endonuclease/exonuclease/phosphatase | ||||
Sequence: ISWNVNGIRAAIKKGFLDYFNEQNADIFCLQETKLSAGQLDLELKGYHQYWNYAEKKGYSGTAIFTKEEPLSVSYGLGIEEHDKEGRVITLEFEKFYMITVYTPNSKDELLRLDYRMVWEDEFRKYLKNLEKKKPVVVCGDLNVAHKEIDLKNPKTNRRNAGFTDEERGKFTELLESGFIDTFRYFYPDLEHAYSWWSYRANARKNNTGWRIDYFVVSKALEKYLVDAEIHAQTEGSDH |
Sequence similarities
Belongs to the DNA repair enzymes AP/ExoA family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length253
- Mass (Da)29,803
- Last updated2018-01-31 v1
- Checksum8A42196A8307BF53
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP024699 EMBL· GenBank· DDBJ | ATV59423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP024702 EMBL· GenBank· DDBJ | ATV66885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PEQY01000001 EMBL· GenBank· DDBJ | PIM79657.1 EMBL· GenBank· DDBJ | Genomic DNA |