A0A2G9ABB7 · A0A2G9ABB7_ECOLX

  • Protein
    L-2-hydroxyglutarate dehydrogenase
  • Gene
    lhgO
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Amino-acid degradation.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Function(S)-2-hydroxyglutarate dehydrogenase activity
Molecular Function2-hydroxyglutarate dehydrogenase activity
Molecular Functionflavin adenine dinucleotide binding
Biological ProcessL-lysine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-2-hydroxyglutarate dehydrogenase
  • EC number
  • Short names
    L2HG dehydrogenase
  • Alternative names
    • L2HG:quinone oxidoreductase

Gene names

    • Name
      lhgO
    • Synonyms
      lhgD
    • ORF names
      FPI65_16400

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC 11230
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A2G9ABB7

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-390FAD dependent oxidoreductase

Sequence similarities

Belongs to the L2HGDH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    422
  • Mass (Da)
    46,014
  • Last updated
    2018-09-12 v1
  • Checksum
    E4EFBF03D135FECD
MYDFVIIGGGIIGMSTAMQLIDVYPDARIALLEKESGPACHQTGHNSGVIHAGVYYTPGSLKAQFCLAGNRATKAFCDQNGIRYDNCGKMLVATSELEMERMRALWERTAANGIDREWLNAEELREREPNITGLGGIFVPSSGIVSYREVTAAMAKIFQARGGEIIYNAEVSALSEHKNGVVICTRQGGEYEASTLISCSGLMADRLVKMLGLEPGFIICPFRGEYFRLAPEHNQIVNHLIYPIPDPAMPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSFSDTLEILGSSGIRRVLQNHLRSGLGEMKNSLCKSGYLRLVQKYCPRLSLSDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRTIHTCNAPSPAATSAIPIGAHIVSKVQTLLASQSNPGRTLRAARSVDALHAAFNQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VLTB01000279
EMBL· GenBank· DDBJ
NDR92810.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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