A0A2G8LA78 · A0A2G8LA78_STIJA
- ProteinGalactose mutarotase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids179 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.
Catalytic activity
- alpha-D-galactose = beta-D-galactoseThis reaction proceeds in the backward direction.
Pathway
Carbohydrate metabolism; galactose metabolism.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | aldose 1-epimerase activity | |
Molecular Function | carbohydrate binding | |
Molecular Function | glucose-6-phosphate 1-epimerase activity | |
Biological Process | galactose metabolic process |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGalactose mutarotase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Echinodermata > Eleutherozoa > Echinozoa > Holothuroidea > Aspidochirotacea > Aspidochirotida > Stichopodidae > Apostichopus
Accessions
- Primary accessionA0A2G8LA78
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length179
- Mass (Da)20,590
- Last updated2018-01-31 v1
- Checksum5291E390697EC537
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MRZV01000152 EMBL· GenBank· DDBJ | PIK57115.1 EMBL· GenBank· DDBJ | Genomic DNA |