A0A2G6P4M5 · A0A2G6P4M5_UNCDL
- ProteinShikimate kinase
- GenearoK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids443 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Catalytic activity
- shikimate + ATP = 3-phosphoshikimate + ADP + H+
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 289-294 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GCGKTT | ||||||
Binding site | 293 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 311 | substrate | ||||
Sequence: D | ||||||
Binding site | 335 | substrate | ||||
Sequence: R | ||||||
Binding site | 357 | substrate | ||||
Sequence: G | ||||||
Binding site | 394 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 408 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | NADP binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Molecular Function | shikimate kinase activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | shikimate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate kinase
- EC number
- Short namesSK
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Candidatus Delongiibacteriota
Accessions
- Primary accessionA0A2G6P4M5
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 33-113 | Shikimate dehydrogenase substrate binding N-terminal | ||||
Sequence: VVGSPIGHSKSPDIFNSIISKYNKKGRYIRLAVSDSSRIIPLCKELNIRGINITSPYKEVLFNELDSYDKISESLEAVNTI | ||||||
Domain | 138-220 | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase | ||||
Sequence: DLKSRSILVIGGGGAAKSVLYALKKFNITITNRTESKGLKLATAFGVKFIQFSDIEKGVKKADIVISTLPDPEIVLKPQWFRK |
Sequence similarities
Belongs to the shikimate kinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length443
- Mass (Da)50,538
- Last updated2018-01-31 v1
- ChecksumD88CCD60A283511A