A0A2G6LMM4 · A0A2G6LMM4_9FLAO

  • Protein
    ATP-dependent zinc metalloprotease FtsH
  • Gene
    ftsH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

168650100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site239-246ATP (UniProtKB | ChEBI)
Binding site462Zn2+ (UniProtKB | ChEBI); catalytic
Active site463
Binding site466Zn2+ (UniProtKB | ChEBI); catalytic
Binding site537Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      CR989_03735
      , CSA39_04570

Organism names

  • Taxonomic identifier
  • Strains
    • DOLJORAL78_35_15
    • DOLZORAL124_35_137
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales

Accessions

  • Primary accession
    A0A2G6LMM4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-40Helical
Transmembrane140-160Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, coiled coil, compositional bias, region.

Type
IDPosition(s)Description
Domain231-371AAA+ ATPase
Coiled coil591-625
Compositional bias648-679Basic and acidic residues
Region648-686Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    686
  • Mass (Da)
    77,056
  • Last updated
    2018-01-31 v1
  • Checksum
    F179FBD5B6DDC43F
MTKNKNKNNDNRPFKEFKFKFNFYWIYAILFALIIGYQFLNSSDLASGKLSENEFTQLLEQNDVKKILVVNDDVAKIYLKPEAFDKPKYKKLKESPFFNENEASYFHEFGDLGKFQEKLEKLKSENNLSFDTSYTTETSIWDGIFMWLPFILIIVIWVYIMRRMSGASGGGGPGGQIFNIGKSRAKLFDQDQKVQTSFKDVAGLEGAKEEIQEIVDFLKNPDKYTKLGGKIPKGALLVGPPGTGKTLLAKAVAGEAKVPFFSLSGSDFVEMFVGVGASRVRDLFKQAAQKSPSIIFIDEIDAIGRARGRNSITGGNDERENTLNQLLTEMDGFGTDTNVIVLAATNRADVLDKALMRAGRFDRQIYVDLPDMNERKEIFEVHIRPLKIYEDVDIKFLAKQTPGFSGADIANVCNEAALVAARKNNKAVHHQDFLDAVDRIVGGLEKKNKIITKKEKKTIAYHEAGHATVSWVLEHAAPLVKVTIVPRGQSLGAAWYLPEERLIVETEQMLDEMCAALGGRAAEKITFGRISTGALSDLEKVTKQARAMVTIYGLNDKLGNITYYDSSGQSDYTFSKPYSEDTAKLIDEEISALIEEQYQRAIKILEKHKEELKTLAELLLEKEVIFSDDLVKIFGERPFKKEPLVEQKSKTIVKEDVPEKSKATQEKQPLNKKDVNNEGEISTEFA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias648-679Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PDQE01000060
EMBL· GenBank· DDBJ
PID69021.1
EMBL· GenBank· DDBJ
Genomic DNA
PDSX01000069
EMBL· GenBank· DDBJ
PIE49056.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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