A0A2G6E752 · A0A2G6E752_9BACT

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site106substrate
Binding site238-240substrate
Binding site247Mn2+ (UniProtKB | ChEBI)
Binding site269Mn2+ (UniProtKB | ChEBI)
Binding site291substrate
Active site293
Binding site309Mn2+ (UniProtKB | ChEBI)
Binding site407-409substrate
Binding site409GTP (UniProtKB | ChEBI)
Binding site441GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      CSB45_06560

Organism names

Accessions

  • Primary accession
    A0A2G6E752

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain51-257Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain266-630Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    653
  • Mass (Da)
    72,133
  • Last updated
    2018-01-31 v1
  • Checksum
    C35A5E622ECADFF0
MLELKKGIDILSEVGGVKTLDEANAVFAERLDQESRDKLSKIKTEEALLKIANAIAMVQADEVFVNTGSQADLQRIREMSIEKGEEKALAMPNHTIHFDLPQDQARLIDKTFYIVNEDEDISSLAQKQLRSEALEHIKTYMPGIGKGKTLMIGFYSRGPVGAAAALPAIEISTSTYVLHSGNILYRSVFEDFDAEVARAGYVITNVHSEGPNRPEDIEHARIYMDRSWLTTFSMFCTYAGNTLLLKKGNHRFAVDLATYYGKEKELSEHMFLTGLTGPNGRKTFFAGAAPSGCGKTTTAMVGSDFIGDDLAQLWISEDGTLRGINPEKGIFGIVEDVNLEGDPFLMKCLREEGTEVIWSNVLIDEHNVPHWVGNGEEAPKKGINFQGEWFEGKSDANGKSIPMSHPNSRCTLENTAIDNYNEEAAEDPKGVEVRVITYSGRDSDTMPPVWVAKTPDAGVVIGASIVSAATATEVGATGVRRQPWANAPFIPGALGDYMDAQFTLFNSDKLKRKPIMAGLNYFLTEGARGGEGKKLLGEKRDVKVWLGWLELYANGDVEAIETPIGFIPKYDDLNKLFAGIRKEYPKALYDKQFSFYLDNIIARIELQEEAYGKGERIPAKLFEIYNAQKAALLAMKERYGSIVSVEKLIEAAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PDPS01000025
EMBL· GenBank· DDBJ
PID57874.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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