A0A2G6D4D3 · A0A2G6D4D3_UNCPS

  • Protein
    Penicillin-binding protein 1B
  • Gene
    mrcB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site227Proton donor; for transglycosylase activity
Active site504Acyl-ester intermediate; for transpeptidase activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentpeptidoglycan-based cell wall
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1B
  • Short names
    PBP-1b
    ; PBP1b
  • Alternative names
    • Murein polymerase

Gene names

    • Name
      mrcB
    • ORF names
      CSB48_01475

Organism names

Accessions

  • Primary accession
    A0A2G6D4D3

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane63-81Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-54Disordered
Domain108-191Bifunctional transglycosylase second
Domain203-374Glycosyl transferase family 51
Domain474-707Penicillin-binding protein transpeptidase

Sequence similarities

In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    809
  • Mass (Da)
    90,653
  • Last updated
    2018-01-31 v1
  • Checksum
    7A1B9B4D09D427C8
MARQGKPDKPARSAGKTSTPAGKGRKQPAKRAGNKTKSRANGKTKSTAGGAPRKQNRRKLSAFLFKLCVLGVVAFAGWLVYLDAVVRDKFEGKMWSIPASVYARPLELYQGAALNPDLLDFELKALGYRHKTGRIETGQYTRQGARFTIAIRPFRFAEEWMPARSVRLEIQGDTIQTLRQTTGQPLDLVRLEPLKIGGIYPRQKEDRILVRLDQVPESLVTALTTIEDKNFWHHHGIAPLSILRALWVNLSAGKVKQGGSTLTQQLVKNFYLDSRRTLFRKVQEALMSVLLELHYSKEQILEAYINEIYLGQSGNRAIHGFAMGSQFYFAKPLQSLNQGELALLVAMVKGPSFYNPRRNPQRARERRNLVLGEMARAGAIEPREAKKIQHTRLRVAERPSFSENLYPAFMDLIRRQLATEYKQEDLESEGLRIFTTLDPQVQHQAENAVRRTMKRLDPSGKKHLQAAMLVTGAESAEVKAIIGDRKPRYAGFNRALDAERPIGSLIKPAVFLTALQHESRYNLNTTISDQPITIELDNKTVWTPQNFEKRSFGNVTLHYALTHSLNISTARLGLSLGVDEVIETLDNLGVDSSALTRYPSLFLGATSMSPWQVTKLYQTIAASGFNLPVRSIRAVATPGGHVLSRYAIDVEQRIDPKTMHLLHYMLQEVMREGTGKSAYSRLPAKLSVAGKTGTTNDHRDSWFAGMTGDYLGIAWIGRDDNGPTRLTGATGALKLWTNTMSRLPQRPFSPVVPDGVEYEWVLDGRPVRTDEGCEGARYLPYIQGTEPTRKQGCLSGIRKIGKWFETIFD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PDPE01000012
EMBL· GenBank· DDBJ
PID44561.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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