A0A2G5XEJ6 · A0A2G5XEJ6_9BACL
- ProteinMultifunctional fusion protein
- GenemsrB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids371 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Catalytic activity
- [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 + CHEBI:57844 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ CHEBI:58772
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 64 | |||||
Sequence: C | ||||||
Active site | 344 | Nucleophile | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | L-methionine:thioredoxin-disulfide S-oxidoreductase activity | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Molecular Function | peptide-methionine (S)-S-oxide reductase activity | |
Biological Process | protein modification process | |
Biological Process | protein repair | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended namePeptide methionine sulfoxide reductase MsrA
- EC number
- Short namesProtein-methionine-S-oxide reductase
- Alternative names
- Recommended namePeptide methionine sulfoxide reductase MsrB
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Planococcaceae > Sporosarcina
Accessions
- Primary accessionA0A2G5XEJ6
Proteomes
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MKLKYLLSLFCILLLAGCGIGNS | ||||||
Chain | PRO_5039617967 | 24-371 | Multifunctional fusion protein | |||
Sequence: DSSTSLGSLTASSDSKYPANPNEDLTFNEENLQDIYLAGGCFWGVEAYMERVYGVYDVTSGFANGTTKNPTYNEVITGKTGHAETVHVQFDPERTDLKTIVEHFFMIVDPTSLNKQGNDRGTQYRSGIYYTNPDDKKIIDEVVTTEQERYDEKIVTEVEPLTSYTLAEEYHQDYLEKNPDGYCHVEFDTLEDQDIPSVIDAANYPKPSDEELKKKLTKAQYQVTQDNNTEAAFSNEYWDTFEDGIYIDVATGEPLFSSADKYDSQCGWPSFTQPIIPEVMTEHTDKSFNMVRTEVRSRAGDSHLGHIFPDGPKDRGGLRYCINSAAIDFVPLEEMEAKGYGYLTSYVK |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 232-355 | MsrB | ||||
Sequence: DEELKKKLTKAQYQVTQDNNTEAAFSNEYWDTFEDGIYIDVATGEPLFSSADKYDSQCGWPSFTQPIIPEVMTEHTDKSFNMVRTEVRSRAGDSHLGHIFPDGPKDRGGLRYCINSAAIDFVPL |
Sequence similarities
Belongs to the MsrA Met sulfoxide reductase family.
Belongs to the MsrB Met sulfoxide reductase family.
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length371
- Mass (Da)41,801
- Last updated2018-01-31 v1
- ChecksumA86137B025311A01