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A0A2G5WXN9 · A0A2G5WXN9_9BACL

  • Protein
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • Gene
    dxr
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10NADPH (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site13NADPH (UniProtKB | ChEBI)
Binding site36NADPH (UniProtKB | ChEBI)
Binding site37NADPH (UniProtKB | ChEBI)
Binding site38NADPH (UniProtKB | ChEBI)
Binding site120NADPH (UniProtKB | ChEBI)
Binding site1211-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site122NADPH (UniProtKB | ChEBI)
Binding site146Mn2+ (UniProtKB | ChEBI)
Binding site1471-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1481-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site148Mn2+ (UniProtKB | ChEBI)
Binding site1721-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1951-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site201NADPH (UniProtKB | ChEBI)
Binding site2081-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2131-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2141-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2171-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site217Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Molecular Functionisomerase activity
Molecular Functionmanganese ion binding
Molecular FunctionNADPH binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • EC number
  • Short names
    DXP reductoisomerase
  • Alternative names
    • 1-deoxyxylulose-5-phosphate reductoisomerase
    • 2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

    • Name
      dxr
    • ORF names
      CSV78_01345

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • P16a
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Planococcaceae > Sporosarcina

Accessions

  • Primary accession
    A0A2G5WXN9

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-1281-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Domain142-2251-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
Domain257-374DXP reductoisomerase C-terminal

Sequence similarities

Belongs to the DXR family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    384
  • Mass (Da)
    42,551
  • Last updated
    2018-01-31 v1
  • MD5 Checksum
    64C9F063C49AA6767EF5ADF807BEB74A
MKKINLLGATGSIGTQTLSIIAAHPDRFELTAMSAGRNIQKVSEIIARFQPKLVSVLEEADAARLKKEFPKVQFVHGDEGLIEAAVGMEADVLLNSVIGSVGLRPTLAAIKAGMTIAIANKETLVAAGNLVVEAAQRHNVPLVPVDSEHSALFQSLNGENPKRITNLILTASGGSFRDYTRDQLQNVTVEQALAHPNWSMGNKLTIDSATMMNKGLEVIEAHHLFAMPYDQIECLLHKESIIHSMVEFEDTSVMAQLGSPDMRVPIQYALTYPDRIQMADAKRLRLDEIGKLHFEKMDYTRFKALSLAYDAGREGGTMPTAMNAANEVAVQLFMEGHISFLQIEEIIEEMMQQHQTIQNPNLEEILETDRNTRKKVYGIVKYQD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PDYN01000001
EMBL· GenBank· DDBJ
PIC68740.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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