A0A2G5WQY1 · A0A2G5WQY1_9BACL

  • Protein
    Phosphoribosylglycinamide formyltransferase
  • Gene
    purN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site14-16N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site67(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site92-95(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site109(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site111Proton donor
Site147Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      CSV78_13165

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • P16a
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Planococcaceae > Sporosarcina

Accessions

  • Primary accession
    A0A2G5WQY1

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-182Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    189
  • Mass (Da)
    20,384
  • Last updated
    2018-01-31 v1
  • Checksum
    7B1A9B3D6FAF4A13
MNKVKIAVFASGSGSNFAALVEACKAGRIPAEIVLMVTDKPDAFVNERANEQGIPIAAIRPRDYETKDAYEQAIRKALQEAQVEWLILAGYMRLIGPVLLEAFPERIINIHPSLLPSFPGKDAIGQAVAAGVKVTGVTVHLVDEGMDTGPILAQRAVDVVDGDVEQTALAIHAVEHELYTATLQNLFKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PDYN01000017
EMBL· GenBank· DDBJ
PIC66361.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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