A0A2G5WKF4 · A0A2G5WKF4_9BACL
- ProteinPyruvate dehydrogenase E1 component subunit alpha
- GenepdhA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids371 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Catalytic activity
- H+ + N6-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate = CO2 + N6-[(R)-S8-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase]
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | pyruvate dehydrogenase (acetyl-transferring) activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyruvate dehydrogenase E1 component subunit alpha
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Planococcaceae > Sporosarcina
Accessions
- Primary accessionA0A2G5WKF4
Proteomes
Interaction
Subunit
Heterodimer of an alpha and a beta chain.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 53-342 | Dehydrogenase E1 component | ||||
Sequence: NRMVYTRILDQRSISLNRQGRLGFYAPTAGQEASQLASQYVLEKDDFILPGYRDVPQLLFHGWPLHMAFLWSRGHYEGSVLPEGLNIFPPQIIIGAQYIQAAGVALGFKKKGQKSVAITYTGDGGTSQGDFYEGLNFAGAFKVPAIFIIQNNQYAISTHRDVQSAAKTLAQKGVAAGVPSVLVDGMDPLAVYVATRDARERAVNGDGPTLIETMCYRYGPHTMAGDDPTRYRTSEIDGEWEKRDPIVRFRTYLENKGIWSKELEEKVVERAKEEIKVAIKKADAAPKQKA |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length371
- Mass (Da)41,542
- Last updated2018-01-31 v1
- ChecksumAC5CA526276123EA