A0A2G5ID46 · CTB4_CERBT
- ProteinCercosporin MFS transporter CTB4
- GeneCTB4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids512 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
MFS transporter; part of the gene cluster that mediates the biosynthesis of cercosporin, a light-activated, non-host-selective toxin (By similarity).
The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules (PubMed:11701851).
These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids (PubMed:11701851).
Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin (By similarity).
The perylenequinone chromophore of cercosporin absorbs light energy to attain an electronically-activated triplet state and produces active oxygen species such as the hydroxyl radical, superoxide, hydrogen peroxide or singlet oxygen upon reaction with oxygen molecules (PubMed:11701851).
These reactive oxygen species cause damage to various cellular components including lipids, proteins and nucleic acids (PubMed:11701851).
Responsible for secretion and accumulation of cercosporin, but does not play any roles in self-protection against the toxicity of cercosporin (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | transmembrane transporter activity |
Names & Taxonomy
Protein names
- Recommended nameCercosporin MFS transporter CTB4
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Dothideomycetidae > Mycosphaerellales > Mycosphaerellaceae > Cercospora
Accessions
- Primary accessionA0A2G5ID46
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 72-92 | Helical | ||||
Sequence: WVITMSLALYALSTTFSSSVF | ||||||
Transmembrane | 110-130 | Helical | ||||
Sequence: VVLGCTSLFMVGFATGPIFWG | ||||||
Transmembrane | 142-162 | Helical | ||||
Sequence: LLAGYLAFAVLQLPIADARSL | ||||||
Transmembrane | 170-190 | Helical | ||||
Sequence: FLGGFFGAAPSSILSGILADI | ||||||
Transmembrane | 202-222 | Helical | ||||
Sequence: TVGAFLTIGPILGPLIGSVLV | ||||||
Transmembrane | 230-250 | Helical | ||||
Sequence: WIANVVAIASFFIAVFTFPFL | ||||||
Transmembrane | 306-326 | Helical | ||||
Sequence: ILLMMTLYVSVSFGLLYNFFL | ||||||
Transmembrane | 343-363 | Helical | ||||
Sequence: ASLPLISILVGVIIAGALLSF | ||||||
Transmembrane | 383-403 | Helical | ||||
Sequence: LLLMMVGAVSLPAGMFLFAWT | ||||||
Transmembrane | 407-427 | Helical | ||||
Sequence: TMNPWPQILSGIPTGFGIHLI | ||||||
Transmembrane | 456-476 | Helical | ||||
Sequence: LFAAGFPILATSMYAAIGVKW | ||||||
Transmembrane | 480-500 | Helical | ||||
Sequence: ILALLAVAMIPIPILFYYFGA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000449867 | 1-512 | Cercosporin MFS transporter CTB4 | |||
Sequence: MALPITDDDLDGLKQPYVTFSSGSASPPQSTTDAMDLEEQVLDAIKSDAFLVDWVGEDDKGNPQNLPYWRKWVITMSLALYALSTTFSSSVFGAATHVLAEEFALPAETVVLGCTSLFMVGFATGPIFWGPFSEAFGRTRPLLAGYLAFAVLQLPIADARSLTSICILRFLGGFFGAAPSSILSGILADIWSPRERGFAMPTVGAFLTIGPILGPLIGSVLVQSVLGWRWIANVVAIASFFIAVFTFPFLPETYTPLLLARRAERMRHMTRNWAYRSKSEEAQSSIGDFAERYLLRPARMLALEPILLMMTLYVSVSFGLLYNFFLAYPTSFIQERGWDQTTASLPLISILVGVIIAGALLSFTTNSRWAPNAKEGRPQETRLLLMMVGAVSLPAGMFLFAWTSSATMNPWPQILSGIPTGFGIHLINMQGMNYIIDSYKIYANSAIAANTFLRSLFAAGFPILATSMYAAIGVKWGTTILALLAVAMIPIPILFYYFGAKIRAKSKWQPPL |
Structure
Sequence
- Sequence statusComplete
- Length512
- Mass (Da)56,047
- Last updated2018-01-31 v1
- ChecksumBD321384E9191C90