A0A2G3JZM0 · A0A2G3JZM0_9NEIS

  • Protein
    UDP-2,3-diacylglucosamine hydrolase
  • Gene
    lpxH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 Mn2+ ions per subunit in a binuclear metal center.

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10Mn2+ 1 (UniProtKB | ChEBI)
Binding site12Mn2+ 1 (UniProtKB | ChEBI)
Binding site43Mn2+ 1 (UniProtKB | ChEBI)
Binding site43Mn2+ 2 (UniProtKB | ChEBI)
Binding site81Mn2+ 2 (UniProtKB | ChEBI)
Binding site81-82substrate
Binding site116Mn2+ 2 (UniProtKB | ChEBI)
Binding site124substrate
Binding site162substrate
Binding site166substrate
Binding site169substrate
Binding site197Mn2+ 2 (UniProtKB | ChEBI)
Binding site197substrate
Binding site199Mn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextrinsic component of plasma membrane
Molecular Functionmanganese ion binding
Molecular FunctionUDP-2,3-diacylglucosamine hydrolase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-2,3-diacylglucosamine hydrolase
  • EC number
  • Alternative names
    • UDP-2,3-diacylglucosamine diphosphatase

Gene names

    • Name
      lpxH
    • ORF names
      CSQ89_18990

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BJB300
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Chitinibacteraceae > Chitinimonas

Accessions

  • Primary accession
    A0A2G3JZM0

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-201Calcineurin-like phosphoesterase

Sequence similarities

Belongs to the LpxH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    248
  • Mass (Da)
    27,436
  • Last updated
    2018-01-31 v1
  • Checksum
    A1FD654A541037C9
MPKPILFASDLHLSDADPATTAAFLAFLHTQVQTASALYLLGDIFEYWIGDDDQNALNGQIAGELRALAKNGVSIFLMHGNRDFLLGPQYAAAAGATLLDDPFILNAFGHKLILSHGDVLCTDDTAYQQFRATVRQPAWQRTFLARPLAERRAEVERIRAASELAKKDKASDIMDVNPHSVANLFVQHTGADLIHGHTHRPARHQHDLAQGTRQRWVLPDWYGGEGGYLQLDETGLSFVGINTNATWR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PDZH01000168
EMBL· GenBank· DDBJ
PHV09929.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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