A0A2E5WMY1 · A0A2E5WMY1_UNCXX

  • Protein
    Phosphoribosylglycinamide formyltransferase
  • Gene
    purN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site725-727N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site782(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site807-810(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site824(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site826Proton donor
Site865Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylamine-glycine ligase activity
Molecular Functionphosphoribosylformylglycinamidine cyclo-ligase activity
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processadenine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      CL656_04765

Organism names

Accessions

  • Primary accession
    A0A2E5WMY1

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain109-313ATP-grasp

Sequence similarities

Belongs to the AIR synthase family.
Belongs to the GART family.
In the C-terminal section; belongs to the GART family.
In the N-terminal section; belongs to the GARS family.
In the central section; belongs to the AIR synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    922
  • Mass (Da)
    104,878
  • Last updated
    2018-01-31 v1
  • Checksum
    62BFD649716EDC37
MKILVVGCGGRENILIQKLKTNNTICCIGPWINPDIHKLCKYYLVTQINEYNVLNYCRVHSDIDYVVIGSETLLETNFVNSCKQLNIKCIGPFRSLAQLETSKYYTRLLLKESNYDCYNPKFNMISGENDIINIIDKYDKFVIKLNGLAGGKGVFVQDDHFKTREEGIKIIKQKIKEESILIEEKLEGQEFSLFTLTDGYSSFHFPPVQDYKRAYDNDNGPNTGGMGSIMTDFDFLNEEDIVKCEEINNNIIRIIQQKYNEPYIGILYGSFMMTNSKQIKLIEYNCRFGDSEVFNLLNSLETDLSIIFKHMAEQRLNELRIEIKIHNSIVKYLVPPGYPNCSEKIKINYKPHNNVYAASIQNNILLGSRAIAVYGEGDTLDEAYNNCEELIKKINYDNLYWRKDIGMRKDAYKMAGVDIDKGNKFVSLIKDSVKSTYNENVLGNYGSFGGQFKLNNNVLVASTDGVGTKSILIKKYKNNYYNCGIDIVNHSINDILVQGAKPLFFLDYIASDKLDLNDSTSFVEGCCVACKKANCVLLGGETAEMPTVYNKGHMDMVGTIVGEKVMNIETVQENDIAIGFSSSGPQTNGYTLIRKIMEKNRPSKIILNQLLSSHQSVLDQINLIHSQFTITGMCHITGGGLTENIKRTLPYDLNIPFDNIDYPLWCKWLKENGNLSDDEMKKVFNCGIGFIVFVRPNETLTEFLIKNNLMNHKPLRIGILGSTRGSNINAIYDAIYNNDTSFLYNKAEIVCTLSNKLNGGILQRCQDLGIHNEYVPSKDYNKNDYDEKLIQIFENFNVDIILCIGYMRILTPIFTNKWKHKCFNVHPSLLPLFSGKMNLDVHKSVLEAGHDKTGCTIHEVTDDVDGGPIILQNMCPVYDNDTPEILKKRVQKLEQESLIELLYNYIHLSGKVIYLNKVNKNI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PBFJ01000026
EMBL· GenBank· DDBJ
MBI96438.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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