A0A2E4LR40 · A0A2E4LR40_UNCDE
- ProteinDihydrolipoyl dehydrogenase
- GenelpdA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids591 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Miscellaneous
The active site is a redox-active disulfide bond.
Catalytic activity
- N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N6-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 168 | FAD (UniProtKB | ChEBI) | |||
Binding site | 231 | FAD (UniProtKB | ChEBI) | |||
Binding site | 296-303 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 319 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 387 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 428 | FAD (UniProtKB | ChEBI) | |||
Binding site | 434-437 | FAD (UniProtKB | ChEBI) | |||
Active site | 560 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dihydrolipoyl dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydrolipoyl dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageBacteria > Myxococcota > Myxococcia
Accessions
- Primary accessionA0A2E4LR40
Proteomes
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 159↔164 | Redox-active | |||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-77 | Lipoyl-binding | |||
Region | 84-111 | Disordered | |||
Compositional bias | 91-111 | Polar residues | |||
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length591
- Mass (Da)63,282
- Last updated2018-01-31 v1
- Checksum5F36483EFF6A1318
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 91-111 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
PAXO01000050 EMBL· GenBank· DDBJ | MBE68767.1 EMBL· GenBank· DDBJ | Genomic DNA |