A0A2E4DCD5 · A0A2E4DCD5_9BACT

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphomonoester.
    EC:3.1.26.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.

Features

Showing features for binding site.

119220406080100120140160180
TypeIDPosition(s)Description
Binding site52Mg2+ 2 (UniProtKB | ChEBI)
Binding site52Mg2+ 1 (UniProtKB | ChEBI)
Binding site92Mg2+ 1 (UniProtKB | ChEBI)
Binding site116Mg2+ 1 (UniProtKB | ChEBI)
Binding site180Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication, removal of RNA primer

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease H
  • EC number
  • Short names
    RNase H

Gene names

    • Name
      rnhA
    • ORF names
      CME62_11860

Organism names

Accessions

  • Primary accession
    A0A2E4DCD5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for coiled coil, domain.

TypeIDPosition(s)Description
Coiled coil4-31
Domain43-188RNase H type-1

Sequence similarities

Belongs to the RNase H family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    192
  • Mass (Da)
    21,248
  • Last updated
    2018-04-25 v1
  • Checksum
    C3E1C1F409B5DA17
MLTSETATAALDVLREEAKQLSDAAVKEKSTSEFEIPEQIQGKDHAFAIYSDGACRGNPGPGSFAFIVQDSKGAILKSNAVAFEQTTNNRMELMGAIAALEEFSVSPMHELYIFTDSKYMVDGMKSWVSGWKKRGWKKADKKEPENLDLWKKLDALAASVNVSFHWVKGHSGHPQNEYVDQLANEVLDANGY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PAVS01000014
EMBL· GenBank· DDBJ
MBD65896.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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