A0A2E0ZRQ3 · A0A2E0ZRQ3_9ACTN

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site72substrate
Binding site211-213substrate
Binding site220Mn2+ (UniProtKB | ChEBI)
Binding site240Mn2+ (UniProtKB | ChEBI)
Binding site262substrate
Binding site263-268GTP (UniProtKB | ChEBI)
Active site264
Binding site287Mn2+ (UniProtKB | ChEBI)
Binding site377-379substrate
Binding site379GTP (UniProtKB | ChEBI)
Binding site410GTP (UniProtKB | ChEBI)
Binding site505-508GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      CL418_04470

Organism names

Accessions

  • Primary accession
    A0A2E0ZRQ3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain12-232Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain236-594Phosphoenolpyruvate carboxykinase C-terminal P-loop
Region344-375Disordered

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    597
  • Mass (Da)
    65,566
  • Last updated
    2018-04-25 v1
  • Checksum
    192775B80237938D
MSATTSNQILVEWVDHWTEVLGPDTVHWCDGTEAEYDALAAGMVASGTFRRLNDDLRPNSYLALSDPEDVARVEDRTFIATKDPLDAGPTNNWRDPYELKAEMTGHFQGAMAGRTMYVVPFSMGPLGSPIAHIGIQLTDSPYVVAGMRXMTRMGRPVLXVLGQGDFVPCVHSVGAPLVDGAEDVSWPCNPDHRYIAHFPKTREIWSYGSGYGGNALLGKKCFALRIASTMAHEDGWLAEHMLXLAVTPPGGERRYVAAAFPSACGKTNMAMMVPTLPGWTVETIGDDIAWMKFXDDGRLYAINPEAGFFGVAPGTSEASNHNAMATLHANAIFTNVARTDDGDVWWEGMTDEPPEHLTDWRGDPWTPDNGSKAAHPNARFTVSAAQCPSIAPEWEDPAGVPISAILFGGRRATNVPLVTEARDWXHGVFLGSIMSSEKTAAASGQTGTVRFDPFAMLPFTGYNVGDYFAHWLEIGARADADRLPKLFWVNWFRRDGDRSFLWPGFGENCRVLDWVLRRVEGTGDAVETPIGLVPTIDAIDRTGIDVDDAAMEQLLDVNQVAWEAELAMIEEHYAAVGERLPVELRRQLDDLRDRLQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PACE01000022
EMBL· GenBank· DDBJ
MAU03116.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp