A0A2D7U0P3 · A0A2D7U0P3_UNCPS

  • Protein
    Multifunctional fusion protein
  • Gene
    nadK
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site312Proton acceptor
Binding site312-313NAD+ (UniProtKB | ChEBI)
Binding site317NAD+ (UniProtKB | ChEBI)
Binding site382-383NAD+ (UniProtKB | ChEBI)
Binding site393NAD+ (UniProtKB | ChEBI)
Binding site410NAD+ (UniProtKB | ChEBI)
Binding site412NAD+ (UniProtKB | ChEBI)
Binding site423-428NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Molecular FunctionNAD+ kinase activity
Molecular Functiontransmembrane transporter activity
Biological ProcessNAD metabolic process
Biological ProcessNADP biosynthetic process
Biological Processphosphorylation
Biological Processqueuosine salvage

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    NAD kinase
  • EC number
  • Alternative names
    • ATP-dependent NAD kinase
  • Recommended name
    Probable queuosine precursor transporter
  • Short names
    Q precursor transporter

Gene names

    • Name
      nadK
    • ORF names
      CMK55_00255

Organism names

Accessions

  • Primary accession
    A0A2D7U0P3

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein
Cytoplasm

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical
Transmembrane37-54Helical
Transmembrane60-84Helical
Transmembrane96-118Helical
Transmembrane138-162Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the NAD kinase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    530
  • Mass (Da)
    58,720
  • Last updated
    2018-01-31 v1
  • Checksum
    9D420F059DA50534
MNLEFFYSNPEILWIVTVLYDLSLAIXLFYFFGKEGLYIAVVLGIILGNLQGGKVSDLEVFGXTFTVSMGAIMYSGIYFATDLLNEKYGRKEATKAVIIGAVANVVVMLTLVLSTLYVPSQISSSAESVHEAXSTLAVYSPIFVIGSITAYLISQSFDVWVFHKIKTITGERMLWLRNNVSTLXSQALDTFIYTFVWVIAGELDFLTALSISLTKYVFKFFIAXXDTFFIYFVKNIRXDEILVSNNXLMKTIKSITVXHSASRNYKEALDLCIGSAKSEDVVIKNVLPVNEKDIDKVIGKKESDLILVIGGDGTMIRTIANLIDHEIPLLGINIGRLGFLTDLNVDSISKVLPEVFSGNYQSEDRPSLNIQVDDSESLIGINEVVFHSGTVAKMLNFSIYQEDILISKHKSDGVIVSSATGSSGYFFSGGGPIIYPTEEVFAILPMFSQSSSSNPLILPNKKKLKIKLKNSVKASIVVDGREDFEVYQGSEIIISKNESSYSLIHPHGYDYFEACRTKLSWGQPLINLDD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NZKD01000001
EMBL· GenBank· DDBJ
MAK14067.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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