A0A2D7U0P3 · A0A2D7U0P3_UNCPS
- ProteinMultifunctional fusion protein
- GenenadK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids530 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Catalytic activity
- NAD+ + ATP = ADP + NADP+ + H+
Cofactor
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 312 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 312-313 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DG | ||||||
Binding site | 317 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 382-383 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: NE | ||||||
Binding site | 393 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 410 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 412 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 423-428 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: SGYFFS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | NAD binding | |
Molecular Function | NAD+ kinase activity | |
Molecular Function | transmembrane transporter activity | |
Biological Process | NAD metabolic process | |
Biological Process | NADP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | queuosine salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended nameNAD kinase
- EC number
- Alternative names
- Recommended nameProbable queuosine precursor transporter
- Short namesQ precursor transporter
Gene names
Organism names
- Organism
- Taxonomic lineageBacteria > Pseudomonadota
Accessions
- Primary accessionA0A2D7U0P3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-32 | Helical | ||||
Sequence: ILWIVTVLYDLSLAIXLFYFF | ||||||
Transmembrane | 37-54 | Helical | ||||
Sequence: LYIAVVLGIILGNLQGGK | ||||||
Transmembrane | 60-84 | Helical | ||||
Sequence: VFGXTFTVSMGAIMYSGIYFATDLL | ||||||
Transmembrane | 96-118 | Helical | ||||
Sequence: AVIIGAVANVVVMLTLVLSTLYV | ||||||
Transmembrane | 138-162 | Helical | ||||
Sequence: VYSPIFVIGSITAYLISQSFDVWVF |
Keywords
- Cellular component
Structure
Family & Domains
Sequence similarities
Belongs to the NAD kinase family.
Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length530
- Mass (Da)58,720
- Last updated2018-01-31 v1
- Checksum9D420F059DA50534