A0A2D7NNV9 · A0A2D7NNV9_UNCDE

Function

function

Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site12-13NAD+ (UniProtKB | ChEBI)
Binding site34NAD+ (UniProtKB | ChEBI)
Binding site78NAD+ (UniProtKB | ChEBI)
Binding site120NAD+ (UniProtKB | ChEBI)
Binding site152-154D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Active site153Nucleophile
Site180Activates thiol group during catalysis
Binding site183D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site212-213D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site235D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site317NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Biological Processglucose metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glyceraldehyde-3-phosphate dehydrogenase
  • EC number

Gene names

    • Name
      gap
    • ORF names
      CL937_02715

Organism names

Accessions

  • Primary accession
    A0A2D7NNV9

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-153Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    336
  • Mass (Da)
    35,912
  • Last updated
    2018-04-25 v1
  • Checksum
    2158C9AF16AEF000
MSINIGINGFGRIGRMVLRAGINNPNIRFVAINDLVPAENLAYLMKYDSTHGRFPGNVETDGNNILIDGKSIECVSERDPEQXGWGDKGVDYVIESTGLFTTLEKAELHLKAGAKKVVISAPAKSKEISTFVMGVNHETYQPSSDQVVSNASCTTNCLAPVVKVLLDNFGIEEGLMTTIHAVTATQPTVDGPSKKDFRGGRGGFQNIIPASTGAAKAVGLCIPEVQGKLTGMAMRVPTANVSVVDLTARLSKSTSYDAINQAMKSASEGPMKGILGYTEEDVVSSDFNGSSLSSIYDAGAGIGLSDQFFKVVSWYDNEMGYSCRLLDLIEYMDSRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NZHX01000036
EMBL· GenBank· DDBJ
MAJ48606.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp