A0A2D3T4B7 · A0A2D3T4B7_9ENTR

Function

function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

Catalytic activity

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.

Features

Showing features for binding site, active site.

116220406080100120140160
Type
IDPosition(s)Description
Binding site225-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site57-595-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site81-835-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site86-87(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)
Active site89Proton donor
Binding site1145-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site128(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentriboflavin synthase complex
Molecular Function6,7-dimethyl-8-ribityllumazine synthase activity
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6,7-dimethyl-8-ribityllumazine synthase
  • EC number
  • Short names
    DMRL synthase
    ; LS
    ; Lumazine synthase

Gene names

    • Name
      ribH
    • ORF names
      BJP41_02270
      , CJJ18_06105

Organism names

  • Taxonomic identifier
  • Strains
    • A2C
    • MI47
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > aphid secondary symbionts > Candidatus Hamiltonella

Accessions

  • Primary accession
    A0A2D3T4B7

Proteomes

Subcellular Location

Interaction

Subunit

Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

Family & Domains

Sequence similarities

Belongs to the DMRL synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    162
  • Mass (Da)
    17,170
  • Last updated
    2018-01-31 v1
  • Checksum
    20340A74D8BDF212
MKIIKGTLVAPNAKIAIAIARFNRFINDSLLSGALDALQRIGQIPEENITVVWVPGAYELPLIVKTLIQTKNYQAVVALGTVIRGSTTHFNYVAGECSAGLSQIAISTDTPVAFGVLTTENIEQAIERAGTKAGNKGADAAIAALEMINLIQTINLNHSTNI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP022932
EMBL· GenBank· DDBJ
ASV34385.1
EMBL· GenBank· DDBJ
Genomic DNA
CP017606
EMBL· GenBank· DDBJ
ATW30640.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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