A0A2D3SZW0 · A0A2D3SZW0_9ENTR
- Protein3-octaprenyl-4-hydroxybenzoate carboxy-lyase
- GeneubiD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
Catalytic activity
- a 4-hydroxy-3-all-trans-polyprenylbenzoate + H+ = a 2-all-trans-polyprenylphenol + CO2
a 4-hydroxy-3-all-trans-polyprenylbenzoate RHEA-COMP:9514 + CHEBI:15378 = a 2-all-trans-polyprenylphenol RHEA-COMP:9516 + CHEBI:16526
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 171 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 174-176 | prenyl-FMN (UniProtKB | ChEBI) | |||
Binding site | 188-190 | prenyl-FMN (UniProtKB | ChEBI) | |||
Binding site | 193-194 | prenyl-FMN (UniProtKB | ChEBI) | |||
Binding site | 237 | Mn2+ (UniProtKB | ChEBI) | |||
Active site | 286 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity | |
Molecular Function | metal ion binding | |
Biological Process | ubiquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-octaprenyl-4-hydroxybenzoate carboxy-lyase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > aphid secondary symbionts > Candidatus Hamiltonella
Accessions
- Primary accessionA0A2D3SZW0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 10-89 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal | |||
Domain | 124-321 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase-likw Rift-related | |||
Domain | 327-451 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal | |||
Sequence similarities
Belongs to the UbiD family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length495
- Mass (Da)55,943
- Last updated2018-01-31 v1
- ChecksumD9B48664B371E852
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017606 EMBL· GenBank· DDBJ | ATW30425.1 EMBL· GenBank· DDBJ | Genomic DNA |