A0A2D2MBF3 · A0A2D2MBF3_9PSED

  • Protein
    Lipoprotein signal peptidase
  • Gene
    lspA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

117120406080100120140160
TypeIDPosition(s)Description
Active site126
Active site145

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      CS390_20650

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HLS-6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A2D2MBF3

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane73-90Helical
Transmembrane97-116Helical
Transmembrane136-157Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    171
  • Mass (Da)
    19,194
  • Last updated
    2018-01-31 v1
  • Checksum
    683B187B0D2D0D2C
MPNPAVGRFGRLSWLWLSVLVLVLDQASKFYFEGLLSLYQQIVVIPDYFSWTLAYNTGAAFSFLADSSGWQRWLFALIALVVSAVLVVWLKRLGRNDTWLAVALALVLGGALGNLYDRIVLGHVIDFILVHWQNRWYFPAFNLADSAITVGAVMLALDMFKSKKSGEPVHD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024478
EMBL· GenBank· DDBJ
ATR84764.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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