A0A2D2M7T4 · A0A2D2M7T4_9PSED

  • Protein
    Lactoylglutathione lyase
  • Gene
    gloA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

Note: Binds 1 nickel ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site93Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site120Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Active site166Proton donor/acceptor
Binding site166Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular Functionlactoylglutathione lyase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lactoylglutathione lyase
  • EC number
  • Alternative names
    • Glyoxalase I

Gene names

    • Name
      gloA
    • ORF names
      CS390_14025

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HLS-6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A2D2M7T4

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-170VOC

Sequence similarities

Belongs to the glyoxalase I family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    173
  • Mass (Da)
    19,617
  • Last updated
    2018-01-31 v1
  • Checksum
    69FC8B9FED1FC342
MSLQHLDTFPGVTAQPDAATQNFVFNHTMLRVKDVAKSLDFYTRVLGFSLVEKRDFPEAEFSLYFLALVDKAQIPSDPAARNTWMKSIPGILELTHNHGTENDPAFAYHNGNTDPRGFGHICISVPDIRAACERFEALGVTFQKRLSDGRMKHLAFIKDPDDYWVEIIQPTEF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024478
EMBL· GenBank· DDBJ
ATR83578.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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