A0A2D2M1H6 · A0A2D2M1H6_9PSED

  • Protein
    Betaine aldehyde dehydrogenase
  • Gene
    betB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 2 potassium ions per subunit.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site27K+ 1 (UniProtKB | ChEBI)
Binding site93K+ 1 (UniProtKB | ChEBI)
Binding site150-152NAD+ (UniProtKB | ChEBI)
Active site162Charge relay system
Binding site176-179NAD+ (UniProtKB | ChEBI)
Binding site230-233NAD+ (UniProtKB | ChEBI)
Binding site246K+ 2 (UniProtKB | ChEBI)
Site248Seems to be a necessary countercharge to the potassium cations
Active site252
Active site252Proton acceptor
Binding site254NAD+ (UniProtKB | ChEBI)
Active site286Nucleophile
Binding site286NAD+ (UniProtKB | ChEBI); covalent
Binding site387NAD+ (UniProtKB | ChEBI)
Binding site457K+ 2 (UniProtKB | ChEBI)
Binding site460K+ 2 (UniProtKB | ChEBI)
Active site464Charge relay system

GO annotations

AspectTerm
Molecular Functionbetaine-aldehyde dehydrogenase activity
Molecular Functionmetal ion binding
Biological Processglycine betaine biosynthetic process from choline

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Betaine aldehyde dehydrogenase
  • EC number
  • Short names
    BADH

Gene names

    • Name
      betB
    • ORF names
      CS390_01820

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HLS-6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A2D2M1H6

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue286Cysteine sulfenic acid (-SOH)

Keywords

Interaction

Subunit

Dimer of dimers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-479Aldehyde dehydrogenase

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    490
  • Mass (Da)
    53,155
  • Last updated
    2018-01-31 v1
  • Checksum
    479182F878F28EC0
MARFELQKLYIDGGYVDAGGDATFEAINPANGEVLAHVQRATKEDVERAVESAERGQKVWAAMTAMQRSRILRRAVDILRERNDELAALETLDTGKSYSETRYVDIVTGADVLEYYAGLVPAIEGEQIPLRDSSFVYTRREPLGVTVGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTSLTTLKLAEIYTEAGLPDGVFNVLTGSGREVGTWLTEHPRVEKVSFTGGTDTGKKVMASASSSSLKEVTMELGGKSPLIICADADLDRAADIAMMANFYSSGQVCTNGTRVFVPAALKAAFEAKIVERVARIRVGNPEDENTNFGPLVSFAHMENVLGYIAKGKEEGARVLCGGERLTTGDFAKGAFVAPTVFTDCRDDMTIVREEIFGPVMSILTYETEEEVIRRANDTDFGLAAGVCTNDLTRAHRIIHQLEAGICWINAWGESPAEMPVGGYKQSGVGRENGISSLAQYTRIKSVQVELGNYNSVF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024478
EMBL· GenBank· DDBJ
ATR81370.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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