A0A2D2LU91 · A0A2D2LU91_MOROS

  • Protein
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • Gene
    nnrD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site295(6S)-NADPHX (UniProtKB | ChEBI)
Binding site356(6S)-NADPHX (UniProtKB | ChEBI)
Binding site421(6S)-NADPHX (UniProtKB | ChEBI)
Binding site458-462AMP (UniProtKB | ChEBI)
Binding site486AMP (UniProtKB | ChEBI)
Binding site487(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase

Gene names

    • Name
      nnrD
    • ORF names
      NP7_04605

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NP7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Moraxella

Accessions

  • Primary accession
    A0A2D2LU91

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-254YjeF N-terminal
Domain254-544YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    547
  • Mass (Da)
    58,329
  • Last updated
    2018-01-31 v1
  • Checksum
    C31EAEE9EF522041
MQSNAQTDKNTVMPNAIALYSPKQIYDLEKNWFSKNDSFALMQQAAWQLAHIIKQESSNQKSSYLQKSSHPQKSVLVVAGAGNNGGDAWLVAHYINQLCPHWSVSVVQVAAPSTLASQTAKHLYQSNCANAAKYLTLTAFLQPIHELGLSYHYDVVIDGLLGIGLNRKPTGDYQTIINWINQYRKQVHACQVISIDVPSGLNAATGEVYDDTAVKADKTLCLIGRKVGLHMGGSKDYVGTVIDVPLLPVEPSGMLLHCTLPNLPQRQQVSHKGTYGHVLIIGGNRLQDGHGMAGAAILAASAALSSGAGKVTVACHGDFHAAIVTALPNAMTADLHNVAGIIELINAVDVVAIGMGLGRDKVTLDLFNQYLTAIKQSQKLCVIDADGLYHLADWAGTSDGLTAPIQPRLGQSNQRFYLTPHSAEAGRLLNQPYADIDRDKISAIRALAHQYGGNWLIKGAQTIVLERDSIDICGLGNAGMATAGMGDCLAGLMASLLAQAIAAPMLTAVLIHAKAGDTLAEKMGEYALQANHMASAIGDIIHQITDD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024443
EMBL· GenBank· DDBJ
ATR78595.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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