A0A2D2LSI4 · A0A2D2LSI4_MOROS

  • Protein
    dITP/XTP pyrophosphatase
  • Gene
    rdgB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site19-24substrate
Active site82Proton acceptor
Binding site82Mg2+ (UniProtKB | ChEBI)
Binding site83substrate
Binding site174-177substrate
Binding site197substrate
Binding site202-203substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      NP7_01030

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NP7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Moraxella

Accessions

  • Primary accession
    A0A2D2LSI4

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    216
  • Mass (Da)
    23,807
  • Last updated
    2018-01-31 v1
  • Checksum
    AFB22A37B92B3250
MSVSILNQLFPTRQLVLASNNQGKLAEFKQLFEQANLEITVIPQGQLGIEDAVEDGLSFIENALIKARHASRISGLPAIADDSGLCVPILGGQPGIYSARFAQDEANFSEHKDLANNQKLLRLLEPHRHTNEPIIGQFVCVLALVRHADDPLPIIAQGIWQGEILPAPQGELGFGYDPLFWAPSVQKSAAEMQKTDKNRISHRGQAMQQLLMQLMK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024443
EMBL· GenBank· DDBJ
ATR77984.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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