A0A2D2E115 · A0A2D2E115_MOROS

  • Protein
    NADH-quinone oxidoreductase subunit C/D
  • Gene
    nuoC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentNADH dehydrogenase complex
Cellular Componentplasma membrane
Molecular FunctionNAD binding
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH:ubiquinone reductase (non-electrogenic) activity
Molecular Functionquinone binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase subunit C/D
  • EC number
  • Alternative names
    • NADH dehydrogenase I subunit C/D
    • NDH-1 subunit C/D

Gene names

    • Name
      nuoC
    • Synonyms
      nuoCD
      , nuoD
    • ORF names
      NP7_03100
      , YHS_03375

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • YHS
    • NP7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Moraxella

Accessions

  • Primary accession
    A0A2D2E115

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-185NADH dehydrogenase I subunit C
Domain40-173NADH:ubiquinone oxidoreductase 30kDa subunit
Region209-594NADH dehydrogenase I subunit D
Domain324-594NADH-quinone oxidoreductase subunit D

Sequence similarities

In the C-terminal section; belongs to the complex I 49 kDa subunit family.
In the N-terminal section; belongs to the complex I 30 kDa subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    594
  • Mass (Da)
    68,685
  • Last updated
    2018-01-31 v1
  • Checksum
    0A97FEF23D8DA439
MVTVTDNQAQTDVPAVIAELNRKFEGQFVVQKTFDAFPTIWVSREQVIEVLLYLRTLPQPYVMLLDISAIDERLRQHRKDRDGNALPDSDFTVFYHLMSLERNTDIRIKVALKEADLHIPTATRIWPNANWYEREAWDMFGITFDGHPHLTRILLPKYWEGHPLRKEYASRATEVPPYYLDKGKQMFEQENLRFVPEEWGMKRSGRDEDFMFLNLGPNHPSAHGAFRVVLQLDGEEVIDCIPDIGYHHRGAEKIAERQTWHSFIPYTDRIDYLGGVMNELPYLMSVEKLAGITVPDRANTIRIMMSEFFRITNNLLYWGTFIQDAGGMTPVFYMFADRQKAYDVIEAVTGYRMHPAWFRIGGTAMDLPNGWHKLVREFLDWMPKRIDEYVKANMKNKVLQLRTQNVAQYDAKSALAWGVSGHGLRATGIPYDVRKARPYLGYENFDFEVPIEFNGDAYDRCLVKIEEIRQSLRIIEQCLNNMPMGAYKADHPLAVPPPKDRTLNDIETLINHFISVSWGPVMPEGESSFMVEAVKGITNYYITSDRSTMSYRTRIRTPTFAHLQQMPSVINGSLVSDLIIYLASIDVVMADVDR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024176
EMBL· GenBank· DDBJ
ATQ82943.1
EMBL· GenBank· DDBJ
Genomic DNA
CP024443
EMBL· GenBank· DDBJ
ATR78333.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp