A0A2D1QGX3 · A0A2D1QGX3_AERSA

Function

function

Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

Catalytic activity

  • Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
    EC:3.1.26.12 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per homotetramer.

Features

Showing features for binding site.

110661002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site302Mg2+ (UniProtKB | ChEBI); catalytic
Binding site345Mg2+ (UniProtKB | ChEBI); catalytic
Binding site403Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site406Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic side of plasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionribonuclease E activity
Molecular FunctionRNA endonuclease activity
Molecular FunctionrRNA binding
Molecular FunctiontRNA binding
Molecular Functionzinc ion binding
Biological ProcessmRNA catabolic process
Biological ProcessrRNA processing
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease E
  • EC number
  • Short names
    RNase E

Gene names

    • Name
      rne
    • ORF names
      Asalp_24850

Organism names

Accessions

  • Primary accession
    A0A2D1QGX3

Proteomes

Subcellular Location

Cytoplasm
Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain39-119S1 motif
Region403-406Required for zinc-mediated homotetramerization and catalytic activity
Region572-751Disordered
Compositional bias583-707Basic and acidic residues
Compositional bias725-744Basic and acidic residues
Region765-828Disordered
Compositional bias772-813Basic and acidic residues
Region1016-1066Disordered

Sequence similarities

Belongs to the RNase E/G family. RNase E subfamily.
Belongs to the RNase E/G family. RNase G subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,066
  • Mass (Da)
    116,490
  • Last updated
    2018-03-28 v1
  • MD5 Checksum
    8FC0BAE69430E54383F7902094E75011
MKRMLINATQEEELRVALVDGQQLYDLDIESPGHEQKKANIYKGKITRVEPSLEAAFVDYGAERHGFLPLKEIARNYFPSGYSYQGRPNIKEVVREGQEVIVQIDKEERGTKGAALTTFISLAGSYLVLMPNNPRAGGISRRIEGDERTELKEALSGLTVPDGMGLIVRTAGVGKSPEELEWDLNVLLNHWDSIHKASQDRTAPVLIHQESNVIVRAIRDYLRRDVGEILIDDPVIFERARAHIELVRPDFLNRVKLYKGEVALFNHFQIESQIESAFQREVRLPSGGSIVIDPTEALTSIDINSSRATKGGDIEETALQTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQREVENRLREAVHQDRARIQLGRISRFGLLEMSRQRLRPSLNESSSHICPRCQGQGVIRDNESLALSILRLIEEEAMKDNTEQVHAQVPVDVAAYLLNEKRASIASLEQRNEVRLYIIPNQHLETPHYEVTRIRQNEIPEAASYELKTEIAKPVYQPKQTQVIEREQPLLQGFVQAPQPAAPAAVAAPVAAPAPIAAKAEAGLFGKLFKAISGLFGSDAAPADVKAPAEKPAVQREARKDEAHRHQRDDTRGRGQRPRRDDNRNSRNTAEAGEKREGAASREGGESRNRRPRKEREPRQEREPRQERETRTEVRSEQRVEREPREPRQEREPRAPRPAREPRAPREPRAEAVVEAVETVETALVSAEPQQEKEQKVAERRERRQLRKQIRADVPASDVAVVPTEAPVAVVADAVEQNDEQADGQRRSRRTPRTQRIEGQRRKRINEDARSQRDDEEPQADTATMTTAAQADAAQVKVEEPAVPVVTIPSAAAIAAAVQASSALTEHVVAEAVAEEAREQAEAAVAVVAAPVVTDTVAEADVAPVAAEPVVAEAVTAPVVAEVTPVIEAAAVEIMTAEVVAATPVVEAPVVAEAAPVAEAATIEAAPAVIETAPVVTADVAVVEPVAEPAAEQPVAKVAVAAPVAKQVNKGAGLLASARKASAPMATPAAAPAQPEREPVEQAPLVRSEVASSGRHAGSTAAVNVATSPAGRP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias583-707Basic and acidic residues
Compositional bias725-744Basic and acidic residues
Compositional bias772-813Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP022426
EMBL· GenBank· DDBJ
ATP09631.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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