A0A2D1GU98 · A0A2D1GU98_RHDV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2338 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Displays NTPase activity, but no helicase activity (By similarity).
Induces the formation of convoluted membranes derived from the host ER (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex (By similarity).
Together with NS2 and NS4, initiates the formation of the replication complex
Induces the formation of convoluted membranes derived from the host ER (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex (By similarity).
Together with NS2 and NS4, initiates the formation of the replication complex
Probable key protein responsible for the formation of membrane alterations by the virus (By similarity).
Induces the formation of convoluted membranes derived from the host ER (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex (By similarity).
Together with NS2 and NTPase, initiates the formation of the replication complex
Induces the formation of convoluted membranes derived from the host ER (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex (By similarity).
Together with NS2 and NTPase, initiates the formation of the replication complex
Together with NTPase and NS4, initiates the formation of the replication complex (By similarity).
Induces the proliferation of the host smooth ER membranes forming long tubular structures (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex
Induces the proliferation of the host smooth ER membranes forming long tubular structures (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex
Catalytic activity
- a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H+ + phosphate
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | host cell cytoplasm | |
Cellular Component | viral capsid | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | ribonucleoside triphosphate phosphatase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | viral RNA genome replication |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
- Alternative names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Lagovirus
- Virus hosts
Accessions
- Primary accessionA0A2D1GU98
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 486-647 | SF3 helicase | ||||
Sequence: QKVISDLHTMVLGKINMTKQRPQPVAVIFKGAPGIGKTYLVHRIARDLGCQHPSTINFGLDHFDSYTGEEVAIADEFNTCGDGESWVELFIQMVNTNPCPLNCDKAENKNKVFNSKYLLCTTNSNMILNATHPRAGAFYRRVMIVEARNKAVESWQATRHGS | ||||||
Domain | 1103-1238 | Peptidase C24 | ||||
Sequence: GLPGFMRHNGSGWMIHIGNGLYISNTHTARSSCSEIVTCSPTTDLCLVKGEVIRSVAQIAEGTPVCDWKKSPISTYGIKKTLSDSTKIDVLAYDGCTQTTHGDCGLPLYDSSGKIVAIHTGKLLGFSKMCTLIDLT | ||||||
Domain | 1489-1613 | RdRp catalytic | ||||
Sequence: SDFLCLDYSKWDSTMSPCVVRLAIDILADCCEQTELTKSVVLTLKSHPMTILDAMIVQTKRGLPSGMPFTSVINSICHWLLWSAAVYKSCAEIGLHCSNLYEDAPFYTYGDDGVYAMTPMMVSLL | ||||||
Region | 1765-1790 | Disordered | ||||
Sequence: RAAPQGETAGTATTASVPGTTTDGMD | ||||||
Compositional bias | 1771-1790 | Polar residues | ||||
Sequence: ETAGTATTASVPGTTTDGMD |
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,338
- Mass (Da)256,269
- Last updated2018-01-31 v1
- Checksum7F00B441CAC1C958
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: L | ||||||
Compositional bias | 1771-1790 | Polar residues | ||||
Sequence: ETAGTATTASVPGTTTDGMD |