A0A2D1GU98 · A0A2D1GU98_RHDV

Function

function

Displays NTPase activity, but no helicase activity (By similarity).
Induces the formation of convoluted membranes derived from the host ER (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex (By similarity).
Together with NS2 and NS4, initiates the formation of the replication complex
Probable key protein responsible for the formation of membrane alterations by the virus (By similarity).
Induces the formation of convoluted membranes derived from the host ER (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex (By similarity).
Together with NS2 and NTPase, initiates the formation of the replication complex
Together with NTPase and NS4, initiates the formation of the replication complex (By similarity).
Induces the proliferation of the host smooth ER membranes forming long tubular structures (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentviral capsid
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein
  • Alternative names
    • p254

Organism names

Accessions

  • Primary accession
    A0A2D1GU98

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain486-647SF3 helicase
Domain1103-1238Peptidase C24
Domain1489-1613RdRp catalytic
Region1765-1790Disordered
Compositional bias1771-1790Polar residues

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    2,338
  • Mass (Da)
    256,269
  • Last updated
    2018-01-31 v1
  • Checksum
    7F00B441CAC1C958
LIGMTTAILPEKKPLNLFLDLRDKTPPCCIRATGKLAWPVFLEQNGEEEPLETCNKCGKWLNGFGYFGLEDLGDVCLCSIAQQKHKFGPVCLCNRAYIHDCGRWRRRSRFLKHYKALNKVIPCAYQFDENFSTPVFEGEVDDLFVELGAPTSMGFIDKKLLKKGKRLMDKFVDVDEPCLTSRDASLLDSIASDNTIRAKLEEEYGVEMVQAARDRKDFMKNLRLALDNRPANPVTWYTKLGNITEKGKQWAKKVVYGACKVTDPLKTLASILLVGLHNVIAVDTTVMLSTFKPVNLLAILMDWTNDLTGFVTTLVRLLELYGVVQATVNLIVEGVKSFWDKVVCATDRCFDLLKRLFDTFEDTVPTGPTAGCLIFMAFVFSTVVGYLPNNSVITTFMKGAGKLTTFAGVIGAIRTLWITINQHMVAKDLTSIQQKVMTVVKMANEAATLDQLEIVSCLCSDLENTLTNRCTLPSYNQHLGILNASQKVISDLHTMVLGKINMTKQRPQPVAVIFKGAPGIGKTYLVHRIARDLGCQHPSTINFGLDHFDSYTGEEVAIADEFNTCGDGESWVELFIQMVNTNPCPLNCDKAENKNKVFNSKYLLCTTNSNMILNATHPRAGAFYRRVMIVEARNKAVESWQATRHGSKPGRSCYSKDMSHLTFQVYPHNMPAPGFVFVGDKLVKSQVAPREHKYSELLDLIKSEHPDVASFEGANKFNFVYPDAQYDQALLMWKQYFVMYGCVARLAKSFVDDIPYNQVHISRASDPKIDGCVEYQCKFQHLWRMVPQFVLGCVNMTNQLGTPLSQQQLDRITNGVEGVTVTTVNNILPFHSQTTLINPSFIKLIWAVRKHLKGLSGVTKVAQFIWRVMTNPVDAYGSLVRTLTGAATFSDDPVSTTIICSNCTIQIHSCGGLLVRYSRDPVPVASDNVDRGDQGVDVFTDPNLISGFSWRQIAHLFVEVVSHLCANHLVNLATMAALGAVATKAFQGVKGKTKRGRGARVNLGNDEYDEWQAARREFVNAHDMTAEEYLAMKNKAAMGSDDQDSIMFRSWWTRRQLRPDEEHVTVVGGGGVRNEVIRTRVRQTPKGPKTLDDGGFYDNDYEGLPGFMRHNGSGWMIHIGNGLYISNTHTARSSCSEIVTCSPTTDLCLVKGEVIRSVAQIAEGTPVCDWKKSPISTYGIKKTLSDSTKIDVLAYDGCTQTTHGDCGLPLYDSSGKIVAIHTGKLLGFSKMCTLIDLTITKGVYETSNFFCGEPIDYRGITAHRLIGAEPRPPVSGTRYAKVPGVPDEYKTGYRPANLGRSDPDSDRSLMNIAVKSLQVYQQEPKLDKVDEFIERAAADVLGYLRFLTKGERQANLNFKAAFNTLDLSTSCGPFVPGKKIDHVKDGVMDQVLAKHLYKCWSVANSGKALHHIYACGLKDELRPLDKVKEGKKRLLWGCDVGVAVCAAAVFHNICYKLKMVARFGPIAVGVDMTSRDVDVIINNLTSKASDFLCLDYSKWDSTMSPCVVRLAIDILADCCEQTELTKSVVLTLKSHPMTILDAMIVQTKRGLPSGMPFTSVINSICHWLLWSAAVYKSCAEIGLHCSNLYEDAPFYTYGDDGVYAMTPMMVSLLPAIIENLRDYGLSPTAADKTEFIDVCPLNKISFLKRTFELTDIGWVSKLDKSSILRQLEWSKTTSRHMMIEETYDLAKEERGVQLEELQVAAAAHGQEFFNFVRKELERQQAYTQFSVYSYDAARKILADRKRVVSVVPDDDFVNVMEGKARAAPQGETAGTATTASVPGTTTDGMDPGVVATTSVVTTENASTSIATAGIGGPPQQVDQQETWRTNFYYNDVFTWSVADAPGNILYTVQHSPQNNPFTAVLSQMYAGWAGGMQFRFIVAGSGVFGGRLVAAVIPPGIEIGPGLEVRQFPHVVIDARSLEPVTITMPDLRPNMYHPTGNPGLVPTLVLSVYNNLINPFGGSTSAIQVTVETRPSEDFEFVMIRAPSSKTVDSISPADLLTTPVLTGVGTDNRWNGEIVGLQPVPGGFSTCNRHWNLNGSTFGWSSPRFAAIDHDRGNASFPGSSSSNVLELWYASAGSAADNPISQIAPDGFPDMSFVPFSGTTIPTAGWVGFGGIWNSNNGAPFVTTVQAYELGFATGAPSNPQPTTTTSGAQIVAKSIYGVANGINQTTAGLFVMASGVISTPNSSAITYTPQPNRIVNAPGTPAAAPIGKNTPIMFASVVRRTGDINAEAGSTNGTQYGAGSQPLPVTVGLSLNNYSSALVPGQFFVWQLNFASGFMELGLSVDGYFYAGTGASATLIDLSELVDIRPVGPRPSTSTLVYNLGGTTNGFSYV

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias1771-1790Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF421600
EMBL· GenBank· DDBJ
ATN96720.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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