A0A2D1A3F1 · A0A2D1A3F1_9APIC

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    cox1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • UN190
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Haemoproteidae > Haemoproteus

Accessions

  • Primary accession
    A0A2D1A3F1

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-39Helical
Transmembrane59-78Helical
Transmembrane113-132Helical
Transmembrane152-172Helical
Transmembrane193-217Helical
Transmembrane237-261Helical
Transmembrane273-297Helical
Transmembrane309-334Helical
Transmembrane346-370Helical
Transmembrane382-403Helical
Transmembrane415-438Helical
Transmembrane458-476Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-477Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    477
  • Mass (Da)
    52,974
  • Last updated
    2018-01-31 v1
  • Checksum
    D70F66FE6B032868
FIVFQRYALITNCNHKTLGLYYLWFSFLFGTYGFLLSIIIRTELYSSSLRIIAQENVNFYNMIFTIHGIIMIFFNIMPGLFGGFGNYFLPILCGSSELAYPRINSISLLLQPIAFGLVILSTAAEFGGGTGWTLYPPLSTSLMSLSPVAVDVIIIGLLVSGVASIMSSLNFITTVVHLRAKGLTLGILSVSTWSILLTAIMLLLTLPVLTGGVLMLLSDLHFNTLFYDPTFSGDPVLYQHLFWFFGHPEVYILILPAFGVISHVISTNYCRSLFGNQSMILAMACIAVLGSIVWAHHMYTTGLEIDTRAYFTSTTILISIPTGTKVFNWLCTYMSSNFGITHNSSLLALLFVCTFTFGGTTGVILGNAAIDIALHDTYYVIAHFHFVLSIGAIIGLFTTISAFQENYFGKHLRDNTIIVLWIMLFFIGVVFTFLPMHFLGFNVMPRRIPDYPDALNGWNMICSLGSTMTLFGLLIFK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY653767
EMBL· GenBank· DDBJ
ATD12886.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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