A0A2C9TKI2 · A0A2C9TKI2_STAAU
- Protein3-isopropylmalate dehydratase large subunit
- GeneleuC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids456 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity
- (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 336 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 396 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 399 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-isopropylmalate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-isopropylmalate dehydratase large subunit
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA0A2C9TKI2
Interaction
Subunit
Heterodimer of LeuC and LeuD.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-446 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | |||
Sequence similarities
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length456
- Mass (Da)50,374
- Last updated2017-12-20 v1
- MD5 Checksum40AF651EB640FA8906FA19274D9CFBB9
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LALJ01000021 EMBL· GenBank· DDBJ | KMR36156.1 EMBL· GenBank· DDBJ | Genomic DNA |