A0A2C8F2Q8 · A0A2C8F2Q8_9BACT

Function

function

Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site27NADPH (UniProtKB | ChEBI)
Binding site28NADPH (UniProtKB | ChEBI)
Binding site29NADPH (UniProtKB | ChEBI)
Binding site30NADPH (UniProtKB | ChEBI)
Binding site53NADPH (UniProtKB | ChEBI)
Binding site55NADPH (UniProtKB | ChEBI)
Binding site140NADPH (UniProtKB | ChEBI)
Binding site1411-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site142NADPH (UniProtKB | ChEBI)
Binding site166Mn2+ (UniProtKB | ChEBI)
Binding site1671-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1681-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site168Mn2+ (UniProtKB | ChEBI)
Binding site1931-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2161-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site222NADPH (UniProtKB | ChEBI)
Binding site2291-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2341-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2351-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2381-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site238Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Molecular Functionisomerase activity
Molecular Functionmanganese ion binding
Molecular FunctionNADPH binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • EC number
  • Short names
    DXP reductoisomerase
  • Alternative names
    • 1-deoxyxylulose-5-phosphate reductoisomerase
    • 2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

    • Name
      dxr
    • ORF names
      DPRO_0004

Organism names

  • Taxonomic identifier
  • Strain
    • 500-1
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfovibrionia > Desulfovibrionales > Desulfovibrionaceae

Accessions

  • Primary accession
    A0A2C8F2Q8

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-1481-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Domain162-2461-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
Domain278-394DXP reductoisomerase C-terminal

Sequence similarities

Belongs to the DXR family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    399
  • Mass (Da)
    42,907
  • Last updated
    2017-12-20 v1
  • MD5 Checksum
    C2B245F211627AA1DB2524A1DB3AC277
MKSYISTWPDNAELPAFPRSLCILGATGSIGTSALKVIKKHPDLFQVTALAGGTNAKRLAQLCTVFRPPYVGVLNDEVRKAFIAYLPCGYKPEIVVGPEGYAELASMEEVDYVLSSIVGAAGFIPTLAAAKAGKMIGLANKESLVLGGHIIRDACHASGATILPVDSEHNALFQGLTGHNGNDELKRLILTASGGPFRGKDREFLKTVTRDQALAHPNWDMGAKISIDSATLMNKGLEVIEACHLYGLPVDLVDVVVHPQSIIHSLVEYIDGSQLAHLGNPDMQVPIAHCLCFPKRVEVDVPQLNLAEIGNLTFEDPDLTAFPCLRLAREAFEAGPSHPIVLNAVNEIAVSSFLDEKIDYLDIPAMIETALEQHVPVDVSTPEAVLDLDRTARKLAGNQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LT907975
EMBL· GenBank· DDBJ
SOB56878.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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