A0A2C8CX35 · A0A2C8CX35_9GAMM
- ProteinDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
- GeneispU
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids256 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
Catalytic activity
- 8 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate
Cofactor
Note: Binds 2 magnesium ions per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 28 | ||||
Binding site | 28 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 29-32 | substrate | |||
Binding site | 33 | substrate | |||
Binding site | 45 | substrate | |||
Binding site | 73-75 | substrate | |||
Active site | 76 | Proton acceptor | |||
Binding site | 77 | substrate | |||
Binding site | 79 | substrate | |||
Binding site | 196 | substrate | |||
Binding site | 201 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 202-204 | substrate | |||
Binding site | 215 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | di-trans,poly-cis-undecaprenyl-diphosphate synthase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | polyprenyltransferase activity | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | polyprenol biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Bruguierivoracaceae > Sodalis
Accessions
- Primary accessionA0A2C8CX35
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length256
- Mass (Da)29,107
- Last updated2017-12-20 v1
- ChecksumE240EF15F4305219
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LT897836 EMBL· GenBank· DDBJ | SNC58313.1 EMBL· GenBank· DDBJ | Genomic DNA |