A0A2B7WFW9 · A0A2B7WFW9_POLH7

Function

function

Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

142350100150200250300350400
TypeIDPosition(s)Description
Active site64N6-GMP-lysine intermediate

GO annotations

AspectTerm
Cellular ComponentmRNA capping enzyme complex
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular FunctionmRNA guanylyltransferase activity
Biological Process7-methylguanosine mRNA capping

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    mRNA-capping enzyme subunit alpha
  • EC number
  • Alternative names
    • GTP--RNA guanylyltransferase
    • mRNA guanylyltransferase

Gene names

    • ORF names
      AJ80_09938

Organism names

  • Taxonomic identifier
  • Strain
    • UAMH7299
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Onygenales incertae sedis > Polytolypa

Accessions

  • Primary accession
    A0A2B7WFW9

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain42-242mRNA capping enzyme adenylation
Domain246-368mRNA capping enzyme C-terminal
Compositional bias381-395Basic and acidic residues
Region381-423Disordered

Sequence similarities

Belongs to the eukaryotic GTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    423
  • Mass (Da)
    49,198
  • Last updated
    2017-12-20 v1
  • Checksum
    C4F2C9B47FBB21B9
MGNYVPDLDAIGIKAEPRLAEQFKREVAALLDRSSLSFPGAQPVSFSARHLQELQRQDYYVVEKTDGIRCLMYFARGDPDSETPEIHYLIDRKNEYRYVPGLHFPMPGDETFQSFHVDTLVDGELVNDTYEDGTEQLKFYVFDCLVLDGKSLMHRTLDKRLAYFKENVLKPYNAMYKRFPDEKRHRKFAVEDKSTQFSYGIEMMFREIIPKVKKIHGNDGLIFTCRSTPYKIGTDEHTLKWKPPLENSVDFRMRLEFPLAEPDEDDEADGITSAYADYDAIPTFHLYVVLSRNEYRHYGVMYVDPDEWESLKALQRPLDDTIVECYRDAQGRWRYLRFRDDKDDANHVSTVEKVLESIEDRVDEDDLIRIAPAIKKAWKARQAQAADEERRRRANGSVSSSGPGQHGMNGIPGGVKRKFEEER

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias381-395Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PDNA01000422
EMBL· GenBank· DDBJ
PGG95566.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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